Clinical study on combined needle-embedding and medication for depressive sleep disorder

摘要

目的

观察埋针结合SSRIs类药物治疗抑郁症睡眠障碍的临床疗效。 方法: 将71例抑郁症患者按入院先后顺序随机分为3 组, 埋针组24 例, 采用埋针结合SSRI类药物治疗; 针刺组21 例, 采用针刺结合SSRI类药物治疗; 药物组26 例, 采用单纯SSRI类药物治疗。 观察3 组治疗前及治疗1、 2、 4、 6 星期后HAMD睡眠积分的差异。

结果

埋针组和针刺组HAMD睡眠积分的改善显著优于药物组, 在治疗1、 2、 4 星期后, 与药物组差异均有统计学意义(P<0.01); 治疗6 星期后, 3 组间差异没有统计学意义。

结论

SSRI类药物治疗可以改善HAMD睡眠积分。 埋针和针刺配合SSRIs类药物改善抑郁症睡眠障碍效果好, 且起效迅速, 疗效优于单纯SSRIs类药物治疗。 埋针组与针刺组差异无统计学意义, 但由于埋针治疗减少了治疗的频次, 故有积极的临床意义。

Abstract

Objective

To observe the clinical efficacy of combined needle-embedding and SSRIs for depressive sleep disorder.

Method

Upon admission, 71 depression cases were randomized into needle-embedding group of 24 cases, using combined needle-embedding and SSRIs, acupuncture group of 21 cases, using combined acupuncture and SSRIs, and medication group of 26 cases, using SSRIs alone. After 1, 2, 4 and 6 weeks of treatment, the HAMD sleep scores were compared.

Result

The HAMD sleep scores in the needle-embedding and acupuncture group were remarkably superior to the medication group and there was significant statistical difference after 1, 2 and 4 weeks of treatment (P<0.01). However, there was no statistical difference after 6 weeks of treatment.

Conclusion

SSRIs can improve HAMD sleep scores. The combined needle-embedding or acupuncture with SSRIs can work faster and better than medication alone. There was no statistical difference between needle-embedding and acupuncture group, however, needle-embedding can reduce the treatment frequencies and therefore has more active clinical meaning.