摘要
目的
观察腹泻型肠易激综合征(irritable bowel syndrome, IBS) 患者结肠粘膜 5-HT变化及隔药灸治疗的临床疗效, 初步探讨其作用机理。
方法
临床收集腹泻型IBS患 者73 例, 随机分为隔药灸组(37 例)和针刺组(36 例)进行治疗, 观察临床疗效, 并 观察隔药灸治疗对典型患者结肠粘膜5-HT表达的影响。
结果
隔药灸组痊愈率为43.2%, 针刺组痊愈率为36.1%, 两组间无统计学差异 (P>0.05); 隔药灸治疗能够改善患者结肠 粘膜5-HT异常增高的表达。
结论
隔药灸能够改善腹泻型IBS临床症状, 可能是通过调 节5-HT表达发挥治疗作用。
Abstract
Objective
To observe the changes of 5-hydroxytryptamine (5-HT) in colonic membrane of diarrhea-predominant irritable bowel syndrome (IBS-D) and the clinical efficacy of herbal cake-partitioned moxibustion in treating it, and to explore the action mechanisms.
Methods
Seventy-three subjects were randomized into two groups: moxibustion group in which 37 cases were treated by herbal cake-partitioned moxibustion and needling group in which 36 cases were treated by needling. The clinical efficacy and 5-HT expression in colonic membrane were observed.
Results
The cure rate was 43.2% in the moxibustion group and 36.1% in the needling group, with no significant difference between the two groups (P>0.05). Herbal cake-partitioned moxibustion could reduce 5-HT expression in colonic membrane.
Conclusion
Herbal cake-partitioned moxibustion might improve the clinical symptoms of IBS-D by reducing 5-HT expression.
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Authors and Affiliations
Additional information
Fund Items: State Administration of TCM of P.R. China (2003ZL23); Shanghai Leading Academic Discipline Project
Author: LIU Hui-rong (1976–), female, associate chief physician
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Liu, Hr., Yang, Y. & Wu, Hg. Clinical study on acupuncture in treating diarrhea-predominant irritable bowel syndrome. J. Acupunct. Tuina. Sci. 6, 360–362 (2008). https://doi.org/10.1007/s11726-008-0360-1
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DOI: https://doi.org/10.1007/s11726-008-0360-1