Résumé
La complexité des pistes physiopathologiques rend la compréhension des mécanismes impliquant le microbiote dans l’intestin irritable très ambitieuse — même si les preuves de son implication s’accumulent. Les grands axes de recherche qui se dégagent — à savoir les rôles des métabolites bactériens issus de l’alimentation, de la micro-inflammation et probablement des acides biliaires — font réfléchir à des axes thérapeutiques : probiotiques et antibiotiques restent peu intéressants en termes de résultats mais « pratiques », et une avancée récente et relativement simple s’est cristallisée à travers le régime d’éviction des FODMAPS (fermentable oligosaccharides, disaccharides, monosaccharides and polyols). Un avenir proche nous dira si la transplantation fécale constituera une alternative thérapeutique intéressante ou non au cours du SII.
Abstract
The complexity of pathophysiological tracks makes the mechanisms involving the microbiota in irritable bowel syndrome hard to decypher- even if the evidence of his involvement accumulate. The main emerging lines of research — namely the roles of bacterial metabolites from food fermentation, micro-inflammation and bile acids — are sobering therapeutic areas: probiotics and antibiotics are moderately interesting, but “convenient”, and a recent and relatively simple advance is to propose an impoverich diet in FODMAPS. Near future will tell if the fecal transplantation constitute an interesting therapeutic alternative or not in the SII.
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Duboc, H. Microbiote et intestin irritable. Colon Rectum 8, 153–156 (2014). https://doi.org/10.1007/s11725-014-0539-1
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DOI: https://doi.org/10.1007/s11725-014-0539-1