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Les lymphomes de l’intestin grêle

Intestinal Lymphomas

  • Dossier Thématique / Thematic File
  • Published:
Côlon & Rectum

Résumé

Les lymphomes intestinaux sont des lymphomes non-hodgkiniens (LNH), moins fréquents que les lymphomes gastriques et aussi issus du tissu lymphoïde associé aux muqueuses (Mucosa Associated Lymphoid Tissue = MALT), normalement présent au niveau de l’intestin grêle et du colon. Ils regroupent différentes entités anatomocliniques qu’il convient de bien connaître car leur origine cellulaire et leur présentation clinique conditionnent leur évolution et leur traitement. Ces dernières années, une meilleure description des profils immuno-histochimiques et des différentes anomalies moléculaires de ces lymphomes, ont contribué à l’amélioration des outils diagnostiques et thérapeutiques et à leur meilleure prise en charge.

La maladie des chaînes lourdes alpha, parmi les lymphomes dits autrefois méditerranéens, représente une forme variante des lymphomes du MALT digestif, qui n’est pratiquement plus rencontrée en Europe, et ne sera pas traitée dans cette revue.

Abstract

Non-Hodgkin intestinal lymphomas are less frequently observed than gastric lymphomas, but also derive from the mucosa-associated lymphoid tissue (MALT) present in a normal intestine. They comprise different clinical and histological entities which should be well defined since their treatment and prognosis will depend on their histological and clinical features. The recent advances in our understanding of immuno-histochemical profiles and different molecular abnormalities of these lymphomas, have contributed to their better diagnosis and clinical management.

The alpha-heavy chain disease, known as Mediterranean lymphoma, which represents another variety of digestive MALT lymphoma, very rarely observed in Europe, will not be addressed in this review.

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Authors and Affiliations

  1. Service de gastroentérologie et oncologie digestive, Hôtel Dieu, 1, Place Alexis Ricordeau, 44093, Nantes, France

    T. Matysiak-Budnik

  2. Service de gastroentérologie, Hôpital Saint Antoine, 75012, Paris, France

    A. Ruskoné-Fourmestraux

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  1. T. Matysiak-Budnik
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  2. A. Ruskoné-Fourmestraux
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Correspondence to T. Matysiak-Budnik.

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Matysiak-Budnik, T., Ruskoné-Fourmestraux, A. Les lymphomes de l’intestin grêle. Colon Rectum 8, 19–24 (2014). https://doi.org/10.1007/s11725-014-0512-z

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  • DOI: https://doi.org/10.1007/s11725-014-0512-z

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