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Douleurs et syndrome de l’intestin irritable : prise en charge thérapeutique à la lumière des nouvelles pistes physiopathologiques

Pain and irritable bowel syndrome : therapeutic options in light of recent pathophysiological approaches

  • Technique / Technique
  • Published:
Côlon & Rectum

Résumé

Le syndrome de l’intestin irritable (SII) est un motif fréquent de consultation pour lequel le praticien est souvent en situation d’échec ou d’insuffisance thérapeutique. Une des explications serait que le SII ne repose pas sur un mécanisme unique, mais sur différents mécanismes physiopathologiques s’exprimant par un même phénotype, la douleur abdominale. Ces dernières années ont été marquées par un démembrement progressif de ce syndrome justifiant une démarche thérapeutique progressive des antispasmodiques aux antidépresseurs ou l’hypnose, assez proche de celles utilisées au cours des douleurs neuropathiques.

Abstract

Irritable bowel syndrome (IBS) occurs frequently. Treatment is often unsuccessful or unable to fully relieve abdominal pain. One explanation suggests that IBS does not result from a single causal mechanism, but rather from different pathophysiological mechanisms expressing the same phenotype, abdominal pain. Several recent studies demonstrated the diversity of IBS, lefting a progressive treatment approach ranging from antispasmodics to antidepressant agents and hypnosis, similar to the approach taken in patients with neuropathic pain.

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Authors and Affiliations

  1. Service d’Hépatogastroentérologie, APHP, hôpital Louis-Mourier, 178, rue des Renouillers, F-92700, Colombes, France

    B. Coffin

  2. Inserm U792, APHP, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, F-92104, Boulogne-Billancourt cedex, France

    B. Coffin

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Coffin, B. Douleurs et syndrome de l’intestin irritable : prise en charge thérapeutique à la lumière des nouvelles pistes physiopathologiques. Côlon Rectum 1, 184–189 (2007). https://doi.org/10.1007/s11725-007-0033-0

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  • DOI: https://doi.org/10.1007/s11725-007-0033-0

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