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Optogénétique et douleur chronique : une stratégie applicable chez l’humain ?

Can we use optogenetics to treat chronic pain?

Douleur et Analgésie volume 29, pages 232–240 (2016)Cite this article

Résumé

Les traitements actuels contre la douleur chronique procurent peu d’analgésie mais d’importants effets secondaires. Une alternative serait de moduler l’activité neuronale directement à l’aide de l’optogénétique, une thérapie génique impliquant l’utilisation de protéines photo-activables. Dans les modèles animaux, cette approche diminue les douleurs inflammatoire et neuropathique. Des avancées spectaculaires permettent d’envisager son application clinique dans les prochaines décennies.

Abstract

The current treatments for chronic pain produce limited efficacy but severe side effects. An alternative strategy is to directly modulate neuronal activity through the use of optogenetics, a gene therapy involving photo-activatable proteins. In animal models, this approach has been shown to decrease inflammatory and neuropathic pain. Recent significant progresses allow to predict clinical applications in analgesia in the next decades.

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Authors and Affiliations

  1. Institut neurologique de Montréal, université McGill, département de neurologie et neurochirurgie, 3801 rue University, bureau 778, Montréal, Québec, Canada, H3A 2B4

    H. Beaudry, I. Daou & P. Séguéla

  2. The Alan Edwards Centre for Research on Pain, université McGill, suite 3100, Genome Building, 740 avenue Doctor Penfield, Montréal, Québec, Canada, H3A 0G1

    H. Beaudry, I. Daou, A. Ribeiro-da-Silva & P. Séguéla

  3. Département de pharmacologie et thérapeutique, université McGill, McIntyre Medical Sciences Building, 3655 promenade Sir-William-Osler, Montréal, Québec, Canada, H3G 1Y6

    H. Beaudry & A. Ribeiro-da-Silva

Authors
  1. H. Beaudry
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  2. I. Daou
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  3. A. Ribeiro-da-Silva
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  4. P. Séguéla
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Corresponding author

Correspondence to P. Séguéla.

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H. Beaudry et I. Daou ont participé à parts égales à cet article.

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Cite this article

Beaudry, H., Daou, I., Ribeiro-da-Silva, A. et al. Optogénétique et douleur chronique : une stratégie applicable chez l’humain ?. Douleur analg 29, 232–240 (2016). https://doi.org/10.1007/s11724-016-0477-9

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  • DOI: https://doi.org/10.1007/s11724-016-0477-9

Mots clés

  • Douleur chronique
  • Optogénétique
  • Photothérapie
  • Analgésie
  • Virus
  • Thérapie génique

Keywords

  • Chronic pain
  • Optogenetics
  • Phototherapy
  • Analgesia
  • Virus
  • Gene therapy