Skip to main content
SpringerLink
Log in

L’évaluation expérimentale de la douleur dans la dépression majeure

Experimental study of pain perception in major depressive disorder

  • Article de Synthèse / Review Article
  • Published:
Douleur et Analgésie

Résumé

Les relations entre la dépression majeure (DM) et la douleur sont plus complexes qu’on ne le croyait originalement. La DM s’accompagne fréquemment de symptômes somatiques douloureux, et elle constitue un facteur de risque dans le développement de la douleur chronique. Paradoxalement, la plupart des études ayant évalué expérimentalement la perception de la douleur dans la DM ont décrit des réponses hypoalgésiques chez les patients. La présente revue de littérature a pour objectif de pondérer les évidences empiriques et d’identifier les facteurs contribuant à l’hétérogénéité des résultats.

Abstract

The relationship between major depressive disorder (MDD) and pain is more complex than originally thought. MDD is frequently accompanied by somatic pain symptoms and is a risk factor for chronic pain. Paradoxically, most experimental studies on pain perception in MDD have described hypoalgesic responses in patients. This literature review aims to evaluate the empirical findings and identify the factors contributing to heterogeneity of results.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Adler G, Gattaz WF (1993) Pain perception threshold in major depression. Biol Psychiatry 34:687–689

    Article  PubMed  CAS  Google Scholar 

  2. Bair MJ, Robinson RL, Katon W, et al (2003) Depression and pain comorbidity: a literature review. Arch Int Med 163:2433–2445

    Article  Google Scholar 

  3. Bär KJ, Wagner G, Koschke M, et al (2007) Increased prefrontal activation during pain perception in major depression. Biol Psychiatry 62:1281–1287

    Article  PubMed  Google Scholar 

  4. Bär KJ, Brehm S, Boettger MK, et al (2005) Pain perception in major depression depends on pain modality. Pain 117:95–103

    Article  Google Scholar 

  5. Bär KJ, Greiner W, Letsch A, et al (2003) Influence of gender and hemispheric lateralization on heat pain perception in major depression. J Psychiatr Res 37:345–353

    Article  PubMed  Google Scholar 

  6. Berna C, Leknes S, Holmes EA, et al (2010) Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol Psychiatry 67:1083–1090

    Article  PubMed  Google Scholar 

  7. Boettger MK, Greiner W, Rachow T, et al (2010) Sympathetic skin response following painful electric stimulation is increased in major depression. Pain 149:130–134

    Article  PubMed  Google Scholar 

  8. Bruder GE, Fong R, Tenke CE, et al (1997) Regional brain asymmetries in major depression with or without an anxiety disorder: a quantitative electroencephalographic study. Biol Psychiatry 41:939–948

    Article  PubMed  CAS  Google Scholar 

  9. Campbell LC, Clauw DJ, Keefe FJ (2003) Persistent pain and depression: a biopsychosocial perspective. Biol Psychiatry 54:399–409

    Article  PubMed  Google Scholar 

  10. Carter LE, McNeil DW, Vowles KE, et al (2002) Effects of emotion on pain reports, tolerance and physiology. Pain Res Manag 7:21–29

    PubMed  Google Scholar 

  11. Celada P, Puig M, Amargos-Bosch M, et al (2004) The therapeutic role of 5-HT1A and 5-HT2A receptors in depression. J Psychiatry Neurosci 29:252–265

    PubMed  Google Scholar 

  12. Dickens C, McGowan L, Dale S (2003) Impact of depression on experimental pain perception: a systematic review of the literature with meta-analysis. Psychosomatic Med 65:369–375

    Article  Google Scholar 

  13. Dworkin RH, Clark CW, Lipsitz JD (1995) Pain responsivity in major depression and bipolar disorder. Psychiatry Res 56:173–181

    Article  PubMed  CAS  Google Scholar 

  14. Fillingim RB, King CD, Ribeiro-Dasilva MC, et al (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10:447–485

    Article  PubMed  Google Scholar 

  15. Fishbain D, Cutler R, Rosomoff H, et al (1997) Chronic painassociated depression: antecedent or consequence of chronic pain? A review. Clin J Pain 13:116–137

    Article  PubMed  CAS  Google Scholar 

  16. Forkmann T, Heins M, Bruns T, et al (2009) The second exteroceptive suppression is affected by psychophysiological factors. J Psychosom Res 66:521–529

    Article  PubMed  Google Scholar 

  17. Frew AK, Drummond PD (2009) Opposite effects of opioid blockade on the blood pressure-pain relationship in depressed and non-depressed participants. Pain 142:68–74

    Article  PubMed  CAS  Google Scholar 

  18. Garcia-Cebrian A, Gandhi P, Demyttenaere K, et al (2006) The association of depression and painful physical symptoms — a review of the European literature. Eur Psychiatry 21:379–388

    Article  PubMed  CAS  Google Scholar 

  19. Gormsen L, Ribe AR, Ran P, et al (2004) Pain thresholds during and after treatment of severe depression with electroconvulsive therapy. Eur J Pain 8:487–493

    Article  PubMed  Google Scholar 

  20. Katona C, Peveler R, Dowrick C, et al (2005) Pain symptoms in depression: definition and clinical significance. Clin Med 5:390–395

    PubMed  Google Scholar 

  21. Klauenberg S, Maier C, Assion HJ, et al (2008) Depression and changed perception: hints for a central disinhibition mechanism. Pain 140:332–343

    Article  PubMed  Google Scholar 

  22. Kleinböhl D, Hölzl R, Möltner A, et al (1999) Psychophysical measures of sensitization to tonic heat discriminate chronic pain patients. Pain 81:35–43

    Article  PubMed  Google Scholar 

  23. Koseka E, Hanssonb P (1997) Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 70:41–51

    Article  Google Scholar 

  24. Lacerda AL, Nicoletti MA, Brambilla P, et al (2003) Anatomical MRI study of basal ganglia in major depressive disorder. Psychiatry Res 124:129–140

    Article  PubMed  Google Scholar 

  25. Large M, Babidge N, Andrews D, et al (2009) Major selfstimulation in first episode of psychosis. Schizophr Bull 35:1012–1021

    Article  PubMed  Google Scholar 

  26. Lautenbacher S, Spernal J, Schreiber W, et al (1999) Relationship between clinical pain complaints and pain sensitivity in patients with depression and panic disorder. Psychsomatic Med 61:822–827

    CAS  Google Scholar 

  27. Lautenbacher S, Roscher S, Strian D, et al (1994) Pain perception in depression: relationships to symptomatology and naloxonesensitive mechanisms. Psychosomatic Med 56:345–352

    CAS  Google Scholar 

  28. Le Bars D, Dickenson AH, Besson JM (1979a) Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 6:283–304

    Article  PubMed  Google Scholar 

  29. Le Bars D, Dickenson AH, Besson JM (1979b) Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 6:305–327

    Article  PubMed  Google Scholar 

  30. Loggia ML, Mogil JS, Bushnell MC (2008) Experimentally induced mood changes preferentially affect pain unpleasantness. J Pain 9:784–791

    Article  PubMed  Google Scholar 

  31. Lopez-Sola M, Pujol J, Hernandez-Ribas R, et al (2010) Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder. Neuropsychopharmacology 35:2305–2317

    Article  PubMed  CAS  Google Scholar 

  32. Marazziti D, Castrogiovanni P, Rossi A, et al (1998) Pain threshold is reduced in depression. Int J Neuropsychopharmacology 1:45–48

    Article  Google Scholar 

  33. Meyer JH (2007) Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 32:86–102

    PubMed  Google Scholar 

  34. Micalos PS, Drinkwater EJ, Cannon J, et al (2009) Reliability of the nociceptive flexor reflex (RIII) threshold and association with pain threshold. Eur J Appl Physiol 105:55–62

    Article  PubMed  Google Scholar 

  35. Millan MJ (2002) Descending control of pain. Prog Neurobiol 66:355–474

    Article  PubMed  CAS  Google Scholar 

  36. Normand E, Potvin S, Gaumond I, et al (2011) Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder. J Clin Psychiatry 72:219–224

    Article  PubMed  Google Scholar 

  37. Orbach I, Mikulincer M, King R, et al (1997) Thresholds and tolerance of physical pain in suicidal and nonsuicidal adolescents. J Consult Clin Psychol 65:646–652

    Article  PubMed  CAS  Google Scholar 

  38. Pinerua-Shuhaibar L, Prieto-Rincon D, Ferrer A, et al (1999) Reduced tolerance and cardiovascular response to ischemic pain in minor depression. J Affect Disord 56:119–126

    Article  PubMed  CAS  Google Scholar 

  39. Potvin S, Marchand S (2008) Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies. Pain 138:70–78

    Article  PubMed  CAS  Google Scholar 

  40. Rainville P, Bao QV, Chrétien P (2005) Pain-related emotions modulate experimental pain perception and autonomic responses. Pain 118:306–318

    Article  PubMed  Google Scholar 

  41. Schmahl C, Greffrath W, Baumgärtner U, et al (2004) Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings. Pain 110:470–479

    Article  PubMed  Google Scholar 

  42. Schwier C, Kliem A, Boettger MK, Bär KJ (2010) Increased cold-pain thresholds in major depression. J Pain 11:287–290

    Article  PubMed  Google Scholar 

  43. Spernal J, Krieg JC, Lautenbacher S (2003) Pain thresholds as a putative functional test for cerebral laterality in major depressive disorder and panic disorder. Neuropsychobiology 48:146–151

    Article  PubMed  Google Scholar 

  44. Stahl S, Briley M (2004) Understanding pain in depression. Hum Psychopharmacol 19:S9–S13

    Article  PubMed  Google Scholar 

  45. Strigo IA, Simmons AN, Matthews SC, et al (2008) Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of “emotional allodynia”. Psychosom Med 70:338–344

    Article  PubMed  Google Scholar 

  46. Strigo IA, Simmons AN, Matthews SC, et al (2008) Major depressive disorder is associated with altered functional brain response during anticipation and processing of heat pain. Arch Gen Psychiatry 65:1275–1284

    Article  PubMed  Google Scholar 

  47. Terhaar J, Boettger MK, Schwier C, et al (2010) Increased sensitivity to heat pain after sad mood induction in female patients with major depression. Eur J Pain 14:559–563

    Article  PubMed  Google Scholar 

  48. Verdu B, Decosterd I, Buclin T, et al (2008) Antidepressants for the treatment of chronic pain. Drugs 68:2611–2632

    Article  PubMed  CAS  Google Scholar 

  49. Von Korff M, Simon G (1996) The relationship between pain and depression. Br J Psychiatry Suppl 30:101–108

    Google Scholar 

  50. Vythilingam M, Charles CH, Tupler LA, et al (2003) Focal and lateralized subcortical abnormalities in unipolar major depressive disorder. Biol Psychiatry 54:744–750

    Article  PubMed  Google Scholar 

  51. Wang W, Fu XM, Wang YH (2000) Temporalis exteroceptive suppression in generalized anxiety disorder and major depression. Psychiatry Res 96:149–155

    Article  PubMed  CAS  Google Scholar 

  52. Weisenberg M, Raz T, Hener T (1998) The influence of filminduced mood on pain perception. Pain 76:365–375

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de psychiatrie, centre de recherche Fernand-Seguin, faculté de médecine, université de Montréal, 7331 Hochelaga, H1N 3V2, Montréal, Québec, Canada

    S. Potvin

Authors
  1. S. Potvin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Potvin.

About this article

Cite this article

Potvin, S. L’évaluation expérimentale de la douleur dans la dépression majeure. Douleur analg 24, 144–151 (2011). https://doi.org/10.1007/s11724-011-0260-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11724-011-0260-x

Mots clés

Keywords

Search

Navigation