Skip to main content
SpringerLink
Log in

Les opioïdes: de l’analgésie à l’hyperalgésie. Des dogmes à réexaminer ?

Opioids revisited: from analgesia to hyperalgesia

  • Revue de la Littérature / Literature Review
  • Published:
Douleur et Analgésie

Résumé

Bien que les substances opioïdes soient les analgésiques de référence pour prendre en charge les douleurs sévères, un certain nombre d’études expérimentales et cliniques indique qu’ils peuvent induire hyperalgésies et allodynies après l’effet analgésique et même faciliter le passage de la douleur aiguë à la douleur chronique. De nouvelles stratégies thérapeutiques que l’on peut qualifier d’antisensibilisation ou d’antihyperalgésie permettent d’améliorer l’efficacité des antalgiques opioïdes.

Abstract

Although opioids are unsurpassed analgesics, experimental and clinical studies show that opioid therapy designed to alleviate moderate to severe pain may unexpectedly render patients more sensitive to nociception (pain vulnerability) leading to hyperalgesia and allodynia and may facilitate the transition from acute to chronic pain. New therapeutic strategies referred to as antihypersensitivity or antihyperalgesic strategies have to be developed for improving the opioid use in patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Références

  1. Angst MS, Clark JD (2006) Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology 104:570–587

    Article  CAS  PubMed  Google Scholar 

  2. Bederson JB, Fields HL, Barbaro NM (1990) Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla. Somatosens Mot Res 7:185–203

    Article  CAS  PubMed  Google Scholar 

  3. Bessiere B, Richebé P, Laboureyras E, et al (2007) Nitrous oxide (N(2)O) prevents latent pain sensitization and long-term anxietylike behavior in pain and opioid-experienced rats. Neuropharmacology 53:733–740

    Article  CAS  PubMed  Google Scholar 

  4. Breivik H, Collett B, Ventafridda V, et al (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10:287–333

    Article  PubMed  Google Scholar 

  5. Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52:77–92

    Article  CAS  PubMed  Google Scholar 

  6. Célèrier E, Laulin J, Larcher A, et al (1999) Evidence for opiateactivatedNMDAprocesses masking opiate analgesia in rats. Brain Res 847:18–25

    Article  PubMed  Google Scholar 

  7. Célèrier E, Laulin JP, Corcuff JB, et al (2001) Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process. J Neurosci 21:4074–4080

    PubMed  Google Scholar 

  8. Célèrier E, Rivat C, Jun Y, et al (2000) Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 92:465–472

    Article  PubMed  Google Scholar 

  9. Goldfarb J, Kaplan EI, Jenkins HR (1978) Interaction of morphine and naloxone in acute spinal cats. Neuropharmacology 17:569–575

    Article  CAS  PubMed  Google Scholar 

  10. Guignard B, Bossard AE, Coste C, et al (2000) Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 93:409–417

    Article  CAS  PubMed  Google Scholar 

  11. Kehlet H, Jensen TS, Woolf CJ (2006) Persistent post-surgical pain: risk factors and prevention. Lancet 367:1618–1625

    Article  PubMed  Google Scholar 

  12. Kim DH, Fields HL, Barbaro NM (1990) Morphine analgesia and acute physical dependence: rapid onset of two opposing, doserelated processes. Brain Res 516:37–40

    Article  CAS  PubMed  Google Scholar 

  13. Koppert W, Schmelz M (2007) The impact of opioid-induced hyperalgesia for postoperative pain. Best Pract Res Clin Anaesthesiol 21:65–83

    Article  CAS  PubMed  Google Scholar 

  14. Laboureyras E, Chateauraynaud J, Richebé P, Simonnet G (2009) Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. Anesth Analg 109:623–631

    Article  CAS  PubMed  Google Scholar 

  15. Laplantine F (1997) Anthropologie de la maladie. Bibliothèque scientifique Payot, Paris

    Google Scholar 

  16. Laulin JP, Célèrier E, Larcher A, et al (1999) Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity. Neuroscience 89:631–636

    Article  CAS  PubMed  Google Scholar 

  17. Le Breton D (2006) Anthropologie de la douleur, Métailié

  18. Le Bars D, Guilbaud G, Jurna I, Besson JM (1976) Differential effects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat. Brain Res 115:518–524

    Article  PubMed  Google Scholar 

  19. Le Roy C, Laboureyras E, Gavello-Baudy S, et al (2009) Abnormal hyperalgesia observed following fentanyl ultra low-dose administration reveals latent pain hypersensitivity induced by prior exposure to opioid-dependent stress in rats. (Soumis)

  20. Mao J, Price DD, Mayer DJ (1994) Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein-kinase C. J Neurosci 14:2301–2312

    CAS  PubMed  Google Scholar 

  21. Nesse RM (1999) Proximate and evolutionary studies of anxiety, stress and depression: synergy at the interface. Neurosci Biobehav Rev 23:895–903

    Article  CAS  PubMed  Google Scholar 

  22. Richebé P, Rivat C, Creton C, et al (2005) Nitrous oxide revisited: evidence for potent antihyperalgesic properties. Anesthesiology 103:845–854

    Article  PubMed  Google Scholar 

  23. Richebé P, Rivat C, Laulin JP, et al (2005) Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. Anesthesiology 102:421–428

    Article  PubMed  Google Scholar 

  24. Rivat C, Laboureyras E, Laulin JP, et al (2007) Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats. Neuropsychopharmacology 32:2217–2228

    Article  CAS  PubMed  Google Scholar 

  25. Rivat C, Laulin JP, Corcuff JB, et al (2002) Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine. Anesthesiology 96:381–391

    Article  CAS  PubMed  Google Scholar 

  26. Rivat C, Richebé P, Laboureyras E, et al (2008) Polyamine deficient diet to relieve pain hypersensitivity. Pain 137:125–137

    Article  CAS  PubMed  Google Scholar 

  27. Siegel S (1976) Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model. Science 193:323–325

    Article  CAS  PubMed  Google Scholar 

  28. Simonin F, Schmitt M, Laulin JP, et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioidinduced tolerance associated with hyperalgesia. Proc Natl Acad Sci USA 103:466–471

    Article  CAS  PubMed  Google Scholar 

  29. Simonnet G, Le Moal M, Vulnerability to opioid tolerance, dependence, and addiction: an individual-centered versus drugcentered paradigm analysis. IASP Book (ed), Pharmacology of pain, chapter 19 “Pharmacology of tolerance, dependence and addiction”, (sous presse)

  30. Solomon RL (1980) The opponent-process theory of acquired motivation: the costs of pleasure and the benefits of pain. Am Psychol 35:691–712

    Article  CAS  PubMed  Google Scholar 

  31. Solomon RL, Corbit JD (1974) An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol Rev 81: 119–145

    Article  CAS  PubMed  Google Scholar 

  32. Stewart WF, Ricci JA, Chee E, et al (2003) Lost productive time and cost due to common pain conditions in the US workforce. JAMA 290:2443–2454

    Article  CAS  PubMed  Google Scholar 

  33. Tirault M, Derrode N, Clevenot D, et al (2006) The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery. Anesth Analg 102:110–117

    Article  CAS  PubMed  Google Scholar 

  34. Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765–1769

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Équipe « Homéostasie-allostasie-pathologie-réhabilitation », université Bordeaux-2, 146, rue Léo-Saignat, F-33076, Bordeaux, France

    G. Simonnet & E. Laboureyras

  2. CNRS UMR 5227, 146, rue Léo-Saignat, F-33076, Bordeaux-II, France

    G. Simonnet & E. Laboureyras

Authors
  1. G. Simonnet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Laboureyras
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Simonnet.

About this article

Cite this article

Simonnet, G., Laboureyras, E. Les opioïdes: de l’analgésie à l’hyperalgésie. Des dogmes à réexaminer ?. Douleur analg 22, 216–228 (2009). https://doi.org/10.1007/s11724-009-0147-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11724-009-0147-2

Mots clés

Keywords

Search

Navigation