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Les canaux ASIC activés par l’acidose extracellulaire dans la douleur chronique

Acid-sensing ion channels (ASICs) in chronic pain

  • Published:
Douleur et Analgésie

Résumé

Les ASIC forment des canaux cationiques activés par une acidification du milieu extracellulaire, qui sont récemment apparus comme des senseurs importants du proton extracellulaire dans le système nerveux central et dans le système nerveux périphérique. Le rôle de ces canaux dans la nociception semble impliquer différentes isoformes à plusieurs niveaux: ASIC3 dans les neurones sensoriels et ASIC1a dans le système nerveux central, qui participe à la sensibilisation dans la moelle épinière et qui module le système opiacé endogène. L’effet analgésique puissant, comparable à celui de la morphine, d’une toxine de mygale capable de bloquer ASIC1a illustre bien le potentiel thérapeutique de ces canaux.

Abstract

Acid-sensing ion channels (ASICs) are protongated cationic channels that have recently been shown to be important sensors for extracellular pH in the central and peripheral nervous systems. The role of ASICs in nociception involves different isoforms at different levels. ASIC3 in sensory neurons and ASIC1a in the central nervous system, which takes part in spinal cord sensitization and modulates the endogenous opioid system. The strong analgesic effect, similar to that of morphine, of a tarantula toxin that can block ASIC1a illustrates the therapeutic potential of these channels.

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  1. Institut de pharmacologie moléculaire et cellulaire, CNRS-Université de Nice-Sophia Antipolis UMR 6097, 660, route des Lucioles, F-06560, Valbonne, France

    E. Lingueglia

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Correspondence to E. Lingueglia.

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Lingueglia, E. Les canaux ASIC activés par l’acidose extracellulaire dans la douleur chronique. Douleur analg 21, 209–214 (2008). https://doi.org/10.1007/s11724-008-0110-7

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  • DOI: https://doi.org/10.1007/s11724-008-0110-7

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