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Homéostasie chlorure et cotransporteurs cation-chlorure, douleur et nociception

Chloride homeostasis and cation-chloride cotransporters, pain and nociception

  • Published:
Douleur et Analgésie

Résumé

En régulant les gradients anioniques, les cotransporteurs cation-chlorure, NKCC1 qui assure l’entrée d’ions chlorures et KCC2 qui en assure la sortie, modulent le système GABAergique et contrôlent les mécanismes de la douleur. Lors d’une inflammation ou d’un traumatisme, l’augmentation de l’activité de NKCC1 dans les neurones sensitifs et/ou la diminution de l’expression de KCC2 dans les neurones spinaux conduisent à la perte du tonus inhibiteur GABAergique et sont responsables de douleurs neuropathiques.

Abstract

By regulating the anionic gradient, two cationchloride cotransporters, NKCC1, which promotes the entrance of chloride ions and KCC2, which promotes their exit, modulate the GABAergic system and control pain mechanisms. Following inflammation or nerve injury, the increase in NKCC1 activity among sensory neurons and/or the decrease in KCC2 expression in spinal neurons, leads to a loss of inhibitory tone and induces neuropathic pain.

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Authors and Affiliations

  1. Inserm U583, 80, rue Augustin-Fliche, F-34000, Montpellier, France

    F. Scamps

  2. Université Montpellier-II, 80, rue Augustin-Fliche, F-34000, Montpellier, France

    S. Pieraut

  3. Inserm U583, université Montpellier-II, 80, rue Augustin-Fliche, F-34000, Montpellier, France

    J. Valmier

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  1. F. Scamps
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  2. S. Pieraut
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  3. J. Valmier
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Correspondence to F. Scamps or J. Valmier.

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Scamps, F., Pieraut, S. & Valmier, J. Homéostasie chlorure et cotransporteurs cation-chlorure, douleur et nociception. Douleur analg 21, 203–208 (2008). https://doi.org/10.1007/s11724-008-0106-3

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  • DOI: https://doi.org/10.1007/s11724-008-0106-3

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