Frontiers of Materials Science

, Volume 11, Issue 1, pp 33–41 | Cite as

Preparation of porous hollow silica spheres via a layer-by-layer process and the chromatographic performance

  • Xiaobing Wei
  • Cairong Gong
  • Xujuan Chen
  • Guoliang Fan
  • Xinhua Xu
Research Article


Hollow silica spheres possessing excellent mechanical properties were successfully prepared through a layer-by-layer process using uniform polystyrene (PS) latex fabricated by dispersion polymerization as template. The formation of hollow SiO2 micro-spheres, structures and properties were observed in detail by zeta potential, SEM, TEM, FTIR, TGA and nitrogen sorption porosimetry. The results indicated that the hollow spheres were uniform with particle diameter of 1.6 μm and shell thickness of 150 nm. The surface area was 511 m2/g and the pore diameter was 8.36 nm. A new stationary phase for HPLC was obtained by using C18-derivatized hollow SiO2 micro-spheres as packing materials and the chromatographic properties were evaluated for the separation of some regular small molecules. The packed column showed low column pressure, high values of efficiency (up to about 43 000 plates/m) and appropriate asymmetry factors.


PS latex layer-by-layer hollow silica spheres packing materials 


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This project was supported by the National Natural Science Foundation of China (Grant No. 51406109).


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.School of Materials Science and EngineeringTianjin UniversityTianjinChina
  2. 2.Analysis and Testing CenterShandong University of TechnologyZiboChina

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