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Frontiers of Materials Science

, Volume 10, Issue 4, pp 358–366 | Cite as

Sodium carboxymethylation-functionalized chitosan fibers for cutaneous wound healing application

  • Dong Yan
  • Zhong-Zheng Zhou
  • Chang-Qing Jiang
  • Xiao-Jie Cheng
  • Ming Kong
  • Ya Liu
  • Chao Feng
  • Xi-Guang Chen
Research Article

Abstract

A water absorption biomaterial, sodium carboxymethylation-functionalized chitosan fibers (Na-NOCC fibers) were prepared, applied for cutaneous wound repair, and characterized by FTIR and NMR. The water absorption of Na-NOCC fibers increased significantly with substitution degree rising, from 3.2 to 6.8 g/g, and higher than that of chitosan fibers (2.2 g/g) confirmed by swelling behavior. In the antibacterial action, the high degree of substitution of Na-NOCC fibers exhibited stronger antibacterial activities against E. coli (from 66.54% up to 88.86%). The inhibition of Na-NOCC fibers against S. aureus were above 90%, and more effective than E. coli. The cytotoxicity assay demonstrated that Na-NOCC2 fibers were no obvious cytotoxicity to mouse fibroblasts. Wound healing test and histological examination showed that significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with Na-NOCC fibers, as compared to those treated with gauze, which demonstrated that Na- NOCC fibers could promote skin repair and might have great application for wound healing.

Keywords

sodium carboxymethylation-functionalized chitosan fiber water absorption wound healing wound dressing 

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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Dong Yan
    • 1
  • Zhong-Zheng Zhou
    • 1
  • Chang-Qing Jiang
    • 1
  • Xiao-Jie Cheng
    • 1
  • Ming Kong
    • 1
  • Ya Liu
    • 1
  • Chao Feng
    • 1
  • Xi-Guang Chen
    • 1
  1. 1.College of Marine Life ScienceOcean University of ChinaQingdaoChina

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