Skip to main content
SpringerLink
Log in

Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering

  • Research Article
  • Published:
Frontiers of Materials Science Aims and scope Submit manuscript

Abstract

A novel composite scaffold based on chitosan-collagen/organomontmorillonite (CS-COL/OMMT) was prepared to improve swelling ratio, biodegradation ratio, biomineralization and mechanical properties for use in tissue engineering applications. In order to expend the basal spacing, montmorillonite (MMT) was modified with sodium dodecyl sulfate (SDS) and was characterized by XRD, TGA and FTIR. The results indicated that the anionic surfactants entered into interlayer of MMT and the basal spacing of MMT was expanded to 3.85 nm. The prepared composite scaffolds were characterized by FTIR, XRD and SEM. The swelling ratio, biodegradation ratio and mechanical properties of composite scaffolds were also studied. The results demonstrated that the scaffold decreased swelling ratio, degradation ratio and improved mechanical and biomineralization properties because of OMMT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Williams D F. The Williams Dictionary of Biomaterials. Liverpool, UK: University Press, 1999

    Google Scholar 

  2. Peter M, Ganesh N, Selvamurugan N, et al. Preparation and characterization of chitosan gelatin/nanohydroxyapatite composite scaffolds for tissue engineering applications. Carbohydrate Polymers, 2010, 80(3): 687–694

    Article  Google Scholar 

  3. Brandi J, Ximenes J C, Ferreira M, et al. Gelcasting of aluminachitosan beads. Ceramics International, 2012, 37: 571–579

    Google Scholar 

  4. Jayakumar R, Menon D, Manzoor K, et al. Biomedical applications of chitin and chitosan based nanomaterials–a short review. Carbohydrate Polymers, 2010, 82(2): 227–232

    Article  Google Scholar 

  5. Dong Y, Feng S S. Poly (D,L-lactide-co-glycolide)/MMT nanoparticles for oral delivery of anticancer drugs release system. Applied Clay Science, 2007, 36: 297–301

    Article  Google Scholar 

  6. Zheng J P, Wang C Z, Wang X X, et al. Preparation of biomimetic three-dimensional gelatin/montmorillonite-chitosan scaffold for tissue engineering. Reactive & Functional Polymers, 2007, 67(9): 780–788

    Article  Google Scholar 

  7. Gieseking J E. The mechanism of cation exchange in the montmorillonite-beidellite-nontronite type of clay minerals. Soil Science, 1939, 47(1): 1–14

    Article  Google Scholar 

  8. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 2006, 27(15): 2907–2915

    Article  Google Scholar 

  9. Olad A, Azhar F F. The synergetic effect of bioactive ceramic and nanoclay on the properties of chitosan-gelatin/nanohydroxypatitemontmorillonite scaffold for bone tissue engineering. Ceramics International, 2014, 40(7): 10061–10072

    Article  Google Scholar 

  10. Zhang Z, Liao L, Xia Z. Ultrasound-assisted preparation and characterization of anionic surfacant modified montmorillonites. Applied Clay Science, 2010, 50(4): 576–581

    Article  Google Scholar 

  11. Sahoo R, Sahoo S, Nayak P L. Synthesis and characterization of polycaprolactone-gelatin nanocomposites for control release anticancer drug paclitaxel. European Journal of Scientific Research, 2011, 48: 527–537

    Google Scholar 

  12. Bin Ahmad M, Lim J J, Shameli K, et al. Synthesis of silver nanoparticles in chitosan, gelatin and chitosan/gelatin bionanocomposites by a chemical reducing agent and their characterization. Molecules, 2011, 16(12): 7237–7248

    Article  Google Scholar 

  13. Zhuang G, Zhang Z, Guo J, et al. A new ball milling method to produce organo-montmorillonite from anionic and nonionic surfactants. Applied Clay Science, 2015, 104: 18–26

    Article  Google Scholar 

  14. Poon L, Wilson L D, Headley J V. Chitosan-glutaraldehyde copolymers and their sorption properties. Carbohydrate Polymers, 2014, 109: 92–101

    Article  Google Scholar 

  15. Freyman T M, Yannas I V, Gibson L J. Cellular materials as porous scaffolds for tissue engineering. Progress in Materials Science, 2001, 46(3–4): 273–282

    Article  Google Scholar 

  16. Lee J H, Park T G, Park H S, et al. Thermal and mechanical characteristics of poly(L-lactic acid) nanocomposite scaffold. Biomaterials, 2003, 24(16): 2773–2778

    Article  Google Scholar 

  17. Marques A P, Reis R L. Hydroxyapatite reinforcement of different starch-based polymers affects osteoblast-like cells adhesion/spreading and proliferation. Materials Science and Engineering C, 2005, 25(2): 215–229

    Article  Google Scholar 

  18. Ehrlich H, Krajewska B, Hanke T, et al. Chitosan membrane as a template for hydroxyapatite crystal growth in a model dual membrane diffusion system. Journal of Membrane Science, 2006, 273(1–2): 124–128

    Article  Google Scholar 

  19. Chesnutt B M, Yuan Y, Brahmandam N, et al. Characterization of biomimetic calcium phosphate on phosphorylated chitosan films. Journal of Biomedical Materials Research Part A, 2007, 82(2): 343–353

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Materials and Chemical Engineering, Hainan University, Haikou, 570228, China

    Xianshuo Cao, Min Liu, Yong Chen, Yang Cao & Xiaolong Yu

  2. College of Ocean, Hainan University, Haikou, 570228, China

    Jun Wang

Authors
  1. Xianshuo Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Min Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yang Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiaolong Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaolong Yu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cao, X., Wang, J., Liu, M. et al. Chitosan-collagen/organomontmorillonite scaffold for bone tissue engineering. Front. Mater. Sci. 9, 405–412 (2015). https://doi.org/10.1007/s11706-015-0317-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11706-015-0317-5

Keywords

Search

Navigation