Abstract
A variety of pyrazole derivatives containing 1,3,4-thiadiazole moiety were synthesized under micro-wave irradiation, and their structures were confirmed by 1H NMR and HRMS. They were evaluated for herbicidal and antifungal activities, and the results indicated that two compounds with a phenyl group (6a) and 4-tert-butylphenyl group (6n) possess good herbicidal activity for dicotyledon Brassica campestris and Raphanus sativus with the inhibition of 90% for root and 80%–90% for stalk at 100 ppm respectively. The structure-activity relationship of compounds 6a and 6n was also studied by density function theory method.
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This work was supported financially by Zhejiang Provincial Science Foundation of China (No. LY16C140007) and Research Institute Special Program of Department of Science and Technology of Zhejiang Province (No. 2015F50030).
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Ding, X., Zhai, Z., Lv, L. et al. Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing 1,3,4-thiadiazole moiety. Front. Chem. Sci. Eng. 11, 379–386 (2017). https://doi.org/10.1007/s11705-017-1634-2
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DOI: https://doi.org/10.1007/s11705-017-1634-2