Skip to main content
SpringerLink
Log in

A novel cataplasma matrix of traditional Chinese medicine

  • Research Article
  • Published:
Frontiers of Chemical Engineering in China Aims and scope Submit manuscript

Abstract

The aim of this paper was to develop a cataplasma matrix that can be applicable to both water-soluble and liposoluble drugs. The gellan gum and konjaku were employed as the scaffold materials of the matrix. With polyacrylic acid sodium and oligosaccharides as tacktifier, the formula of the cataplasma matrix was optimized in the orthogonal method as: gellan gum 0.4 g, xanthan gum 0.03 g, konjac glue 0.1 g, glycerin 4 g, Gluco-Adhesive T (GAT) 6 g, Gluco-Adhesive E (GAE) 6 g, polyacrylic acid sodium 0.22 g, and sorbitol 3 g. The 180° peel strength, the tensile strength and the elongation at break was 3.043 N, 0.275 MPa and 91.05%, respectively. Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcumin, which were used as the models of hydrophilic, poor-water-soluble and hydrophobic ingredients. The drug contents could reach 4.12%, 2.42% and 3.75%, while the in vitro release rate were measured as, 361.79, 55.85 and 104.41 μg·cm−2·h−1 for baicalin, berberine and curcumin, respectively. These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Miller M A, Pisani E. The cost of unsafe injections. Bull World Health Organ, 1999, 77: 808–811

    CAS  Google Scholar 

  2. Mark R P, Robert L. Transdermal drug delivery. Nat Biotechnol, 2008November, 26(11): 1261–1268

    Article  Google Scholar 

  3. Amanda MB, Kelly MS. Optimizing transdermal drug therapy. Am Health-Syst Pharm, 2008, 65: 1337–1346

    Article  Google Scholar 

  4. Zhao B, Song X H, Wang F. Hydrophilic cataplasma matrix of Traditional Chinese Medicine. Chinese Archives of Traditional Chinese Medicine, 2008, 26(6): 1276–1278

    Google Scholar 

  5. Li Y, He W, Chang C, He Y H, He P P. Study on matrix of hydrophilic cataplasm. China pharmacist, 2006, 9(10): 911–913 (in Chinese)

    CAS  Google Scholar 

  6. Zhang I, Shung K K, Edwards D A. Hydrosels with enhanced mass transfer transdemal drug. Pharm Sci, 1996, 85(2): 1312–1316

    Article  CAS  Google Scholar 

  7. Zhang H, Niu X, Yang X Z. Optimization on formula ratio of matrix in Naru23 Cataplasm through orthogonal test. Journal of Beijing University of Traditional Chinese Medicine, 2008, 31(5): 338–339 (in Chinese)

    CAS  Google Scholar 

  8. Jia W, Gao W Y, Wang T, Liu Y B, Xue J, Xiao P G. Cataplasma of traditional Chinese medicine. China Journal of Chinese Materia Medica, 2003, 28(1): 10–11 (in Chinese)

    Google Scholar 

  9. Song J C, Huang L, Chen J L. Study on preparation and in vitro release behavior of lung targeting hydroxycamptothecin liposomes. Chinese Journal of Immunology, 2008, 43: 1564–1568 (in Chinese)

    CAS  Google Scholar 

  10. Zhou X Q, Liu H Y, Zhao T. Preparation of baicalin cataplasma. Fine Chemicals, 2007, 24(8): 778–780 (in Chinese)

    CAS  Google Scholar 

  11. Mei C L, Zhou J. Practical Statistical Method. Beijing: Science Press, 2002 (in Chinese)

    Google Scholar 

  12. Zhen P, Fan X J, Ma L, Guan Z, Lu W, Hu X. Application of fuzzy analytical method in the optimization of liposome preparation by orthogonal experiments. Journal of Chinese Pharmaceutical Sciences, 2008, 18: 37–42 (in Chinese)

    Google Scholar 

  13. R Potts R O, McNeill S C, Desbonnet C R, Wakshull E. Transdermal drug transport and metabolism II. The role of competing kinetic events. Pharmaceutical Research, 1989, 6(2): 119–124

    Article  Google Scholar 

  14. Lee P S. Transdermal hormone therapy and bone health. Clinical Interventions in Aging, 2008: 3(1): 51–54

    Google Scholar 

  15. Hao B H, Ma L, Xu H R. The research for the absorption function of fragrant traditional Chinese medicine drug to capsaicin. Nat Prod Res Dev, 2006, 18: 637–639

    Google Scholar 

  16. Teske J, Weller J P, Larsch K, Tröger H D, Karst M. Fatal outcome in a child after ingestion of a transdermal fentanyl patch. Int J Legal Med, 2007, 121: 147–151

    Article  Google Scholar 

  17. Rudolf L. Transdermal buprenorphine in the management of persistent pain—safety aspects. Therapeutics and Clinical Risk Management, 2006: 2(1): 115–125

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

    Jing Tian

  2. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China

    Jing Tian

  3. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Xiaolei Zhang & Xueqin Zhou

Authors
  1. Jing Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaolei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xueqin Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xueqin Zhou.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tian, J., Zhang, X. & Zhou, X. A novel cataplasma matrix of traditional Chinese medicine. Front. Chem. Eng. China 4, 91–95 (2010). https://doi.org/10.1007/s11705-009-0304-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11705-009-0304-4

Keywords

Search

Navigation