Skip to main content
SpringerLink
Log in

Crystal modification of rifapentine using different solvents

  • Research Article
  • Published:
Frontiers of Chemical Engineering in China Aims and scope Submit manuscript

Abstract

Rifapentine crystals with different habits were prepared by recrystallization from selected solvents, such as methanol, ethanol, chloroform, and acetic acid. Scanning electron microscopy, X-ray powder diffractometry, infrared spectrometry, and differential scanning calorimetry were used to investigate the physicochemical characteristics of the prepared crystals. The comparative dissolution behaviors of the newly developed crystals and of rifapentine without being treated were also studied. Results show that the newly developed crystals were different from each other with respect to physical properties but were identical chemically. Needle-shaped crystals were obtained from methanol, ethanol, and chloroform solvents, and the block-shaped crystals were obtained from acetic acid solvent. X-ray diffraction spectra and differential scanning calorimetry investigation on those developed crystals clearly indicate that rifapentine has different crystal structure modification. When the crystal was obtained from acetic acid, the change of crystal habit was originated from the crystal structure modification. The dissolution rate of newly developed crystals was found to be higher than that of rifapentine without being treated. However, the modified crystal obtained from acetic acid shows the lower dissolution rate than crystals obtained from other solvents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kapoor A, Majumdar D K, Yadav, M R. Crystal forms of nimesulide-asulfonanilide (non-steriodal anti inflammatory drug). Indian J Chem, 1988, 37B: 572–575

    Google Scholar 

  2. Shekunov B Y, Grant D J W, Latham R J, Sherwood J N. In situ optical interferometric studies of the growth and dissolution behavior of paracetamol (acetaminophen) crystals. 3: Influence of growth in the presence of p-acetoxyacetanilide. J Phys Chem, 1997, B101: 9107–9112

    Google Scholar 

  3. Nokhodchi A, Bolourtchian N, Dinarvand R. Crystal modification of phenytoin using different solvents and crystallization conditions. Int J Pharm, 2003, 250: 85–97

    Article  CAS  Google Scholar 

  4. Adhiyaman R, Basu S K. Crystal modification of dipyridamole using different solvents and crystallization conditions. Int J Pharm, 2006, 321: 27–34

    Article  CAS  Google Scholar 

  5. Finnie S, Ristic R I, Sherwood J N, Zikic A M. Characterisation of growth behaviour of small paracetamol crystals grown from pure solutions. Chem Eng Res Design (Trans IChemE), 1996, A74: 835–838

    Google Scholar 

  6. Chen J X, Wang J K, Zhang Y, Wu H, Chen W, Guo Z C. Crystal growth, structure and morphology of hydrocortisone methanol solvate. J Crystal Growth, 2004, 265: 266–273

    Article  CAS  Google Scholar 

  7. Prasad K V R, Ristic R I, Sheen D B, Sherwood J N. Crystallization of paracetamol from solution in the presence and absence of impurity. Int J Pharm, 2001, 215: 29–24

    Article  CAS  Google Scholar 

  8. Chow A H L, Grant D J W. Modification of acetaminophen crystals. III: Influence of initial supersaturation during solution-phase growth on crystal properties in the presence and absence of p-acetoxyacetanilide. Int J Pharm, 1988, 42: 123–133

    Article  CAS  Google Scholar 

  9. Zhou K, Li J, Ren Y S. Solubility of rifapentine in different organic solvents. J Chem Eng Data, 2008, 53: 998–999

    Article  CAS  Google Scholar 

  10. Zhou K, Li J, Zheng D S. Solubility of rifapentine in the binary system of acetic acid and n-octanol solvent mixtures. J Chem Eng Data, 2008, 53: 1978–1979

    Article  CAS  Google Scholar 

  11. Nie Q, Wang J K, Wang Y L, Bao Y. Effects of solvent and impurity on crystal habit Modification of 11α-Hydroxy-16α, 17α-epoxyprogesterone. Chin J Chem Eng, 2007, 15: 648–653

    Article  CAS  Google Scholar 

  12. Hassan M A, Salem M S, Sueliman M S, Najib N M. Characterization of famotidine polymorphic forms. Int J Pharm, 1997, 149: 227–232

    Article  CAS  Google Scholar 

  13. Dalton J T, Straughn A B, Dickason D A, Grandolfi G P. Predictive ability of level A in vitro-in vivo correlation for ringcap controlled-release acetaminophen tablets. Pharm Res, 2001, 18: 1729–1734

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Chemical Engineering, Sichuan University, Chengdu, 610065, China

    Kun Zhou, Jun Li, Jianhong Luo & Dongsheng Zheng

Authors
  1. Kun Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jun Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jianhong Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dongsheng Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhou, K., Li, J., Luo, J. et al. Crystal modification of rifapentine using different solvents. Front. Chem. Eng. China 4, 65–69 (2010). https://doi.org/10.1007/s11705-009-0302-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11705-009-0302-6

Keywords

Search

Navigation