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Recent developments in the chemistry of Negishi coupling: a review

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Negishi cross-coupling reaction is a familiar reaction for the formation of carbon–carbon bonds that couples organic halides or triflates with organozinc compounds. Palladium is used as a metal catalyst, sometimes nickel can also be used, e.g. Pd2(dba)3, PdCl2(P(otol)3)2, Pd(DPEPhos)Cl2, Ni(PPh3)2Cl2, etc. This reaction has vast applications in organic synthesis as many natural products and biologically active compounds can be obtained through this reaction. The main aim of this review is to summarize the recent synthetic applications of the Negishi reaction reported since 2011 which may be helpful to the researchers working on the development of mild and sustainable strategies regarding the synthesis of pharmaceutically important scaffolds.

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The authors are thankful to GC University, Faisalabad, for providing the facilities to carry out this work.

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Correspondence to Ameer Fawad Zahoor or Rabia Akhtar.

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Muzammil, Zahoor, A.F., Parveen, B. et al. Recent developments in the chemistry of Negishi coupling: a review. Chem. Pap. 78, 3399–3430 (2024).

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