Abstract
ZnO nanoparticles (NPs) have shown high potential in various antibacterial applications. This study greenly synthesized ZnO NPs at different sizes using Paederia lanuginosa aqueous leaf extract and active compounds in Paederia lanuginosa ethanol extract were incorporated into the ZnO NPs to form different ZnO-extract nanoformulations. Chemical methods, FeSEM, UV–Vis, FTIR, EDX spectra, XRD, DLS, and TGA were used to characterize the synthesized extracts, ZnO NPs, and their nanoformulations. The results show that the ZnO NPs had the size of 20–30, 50–70, or 100–150 nm. Organic substances including phenolics, glycosides, and iridoids were present in the nanoformulations. The nanoformulations enlarge the inhibition zone of ZnO nanoparticles against E. coli ATCC 25922 and are potential for antibacterial applications.
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Agarwal H, Venkat Kumar S, Rajeshkumar S (2017) A review on green synthesis of zinc oxide nanoparticles—an eco-friendly approach. Resource-Efficient Technol 3(4):406–413. https://doi.org/10.1016/j.reffit.2017.03.002
Ahmed S, Annu SA, Chaudhry SI (2017) A Review on biogenic synthesis of Zno nanoparticles using plant extracts and microbes: a prospect towards green chemistry. J Photochem Photobiol, B 166:272–284. https://doi.org/10.1016/j.jphotobiol.2016.12.011
Albanese A, Tang PS, Chan WCW (2012) The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 14:1–16. https://doi.org/10.1146/annurev-bioeng-071811-150124
Aminuzzaman, M, Lim PY, Wee-Shenog G, Akira W (2018) Green synthesis of zinc oxide nanoparticles using aqueous extract of Garcinia Mangostana fruit pericarp and their photocatalytic activity. Bull Mater Sci 41(2). https://doi.org/10.1007/s12034-018-1568-4.
Anh NT, Vân LT, Như Q, Anh TTQ, Thảo PĐD, Thảo ĐTT, Huế NV (2019) Study on antioxidant activities of Paederia lanuginosa wall extract. Tạp Chí Khoa Học & Công Nghệ Nông Nghiệp 3(2):1359–1370
Attia GH, Yasmine SM, Mahmoud Y, Ammar MI, Randa A, El Raey MA (2021) antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as Anti-SARS-CoV-2. Colloids Surfaces B Biointerfaces 203 (January):111724. https://doi.org/10.1016/j.colsurfb.2021.111724.
Basnet PT, Inakhunbi C, Dhrubajyoti S, Somenath C (2018) A review on bio-synthesized zinc oxide nanoparticles using plant extracts as reductants and stabilizing agents. J Photochem Photobiol B Biol 183. https://doi.org/10.1016/j.jphotobiol.2018.04.036.
Chanda S, Deb L, Tiwari RK, Singh K, Ahmad S (2015) Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India. BMC Complement Altern Med 15(1):304. https://doi.org/10.1186/s12906-015-0831-0
Chauke N, Siebrits FK (2012) Evaluation of silver nanoparticles as a possible coccidiostat in broiler production. South Afr J Anim Sci 42(5). https://doi.org/10.4314/sajas.v42i5.10.
Đàm VH (2019) “Phân Tích Thành Phần Hóa Học Của Lá Mơ Lông Việt Nam (Paederia lanuginosa).” Đại học quốc gia Hà Nội.
El-Megharbel SM, Mohammed A, Fawziah AA, Reham ZH (2021) Utilizing of (zinc oxide nano-spray) for disinfection against ‘Sars-Cov-2’ and testing its biological effectiveness on some biochemical parameters during (covid-19 pandemic)—”zno nanoparticles have antiviral activity against (Sars-Cov-2). Coatings 11(4). https://doi.org/10.3390/coatings11040388.
Erdenechimeg Ch, Guiqide A, Dejidmaa B, Chimedragchaa Ch, Purevsuren S (2017) Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-Tang on lipopolysaccharide-induced acute lung injury in rats. Braz J Med Biol Res 50(12):6–11. https://doi.org/10.1590/1414-431X20175916
Fadwa AO, Albarag AM, Alkoblan DK, Mateen A (2021) Determination of synergistic effects of antibiotics and Zno NPs against Isolated E. coli and A. baumannii bacterial strains from clinical samples. Saudi J Biol Sci 28(9):5332–5337. https://doi.org/10.1016/j.sjbs.2021.05.057
Gahlawat G, Shikha S, Chaddha BS, Chaudhuri SR, Mayilraj S, Choudhury AR (2016) Microbial glycolipoprotein-capped silver nanoparticles as emerging antibacterial agents against cholera. Microb Cell Fact 15(February):25. https://doi.org/10.1186/s12934-016-0422-x
Gao Q, Luping Z, Shuai X, Shuqi D, Qi Z, Yuliang L (2023) Significant improvement and mechanism of tetracycline degradation with the synergistic piezoelectric effect of ZnO/CuS Z-scheme heterojunction photocatalysts. Environ Sci Nano 10(2):581–594. https://doi.org/10.1039/D2EN01033J.
Goh EG, Xu X, McCormick PG (2014) Effect of particle size on the UV absorbance of zinc oxide nanoparticles. Scripta Mater 78–79:49–52. https://doi.org/10.1016/j.scriptamat.2014.01.033
Gonzales-Eguia A, Chao-Ming Fu, Fu-Yin Lu, Lien T-F (2009) Effects of nanocopper on copper availability and nutrients digestibility, growth performance and serum traits of piglets. Livest Sci 126(1):122–129. https://doi.org/10.1016/j.livsci.2009.06.009
Hafeez M, Rabia A, Muhammad UH, Bilal A, Muhammad NA, Syed AK, Ikhtiar A, Shaukat A (2019) Populus ciliata leaves extract mediated synthesis of zinc oxide nanoparticles and investigation of their anti-bacterial activities. Mater Res Express 6 (7). https://doi.org/10.1088/2053-1591/ab19c8.
Happy A, Menon S, Venkat Kumar S, Rajeshkumar S, David Sheba R, Lakshmi T, Deepak Nallaswamy V (2019) Phyto-assisted synthesis of zinc oxide nanoparticles using cassia alata and its antibacterial activity against Escherichia coli. Biochem Biophys Reports 17 (December 2018): 208–211. https://doi.org/10.1016/j.bbrep.2019.01.002.
Huang S, Chen JC, Hsu CW, Chang WH (2009) Effects of nano calcium carbonate and nano calcium citrate on toxicity in ICR mice and on bone mineral density in an ovariectomized mice model. Nanotechnology 20(37):375102. https://doi.org/10.1088/0957-4484/20/37/375102.
Huong LTT, Nam NH, Doan DH, Nhung HTM, Quang BT, Nam PH, Thong PQ, Phuc NX, Thu HP (2016) Folate attached, curcumin loaded Fe3O4 nanoparticles: a novel multifunctional drug delivery system for cancer treatment. Mater Chem Phys 172:98–104. https://doi.org/10.1016/j.matchemphys.2015.12.065
Kaningini AG, Azizi S, Sintwa N, Mokalane K, Mohale KC, Mudau FN, Maaza M (2022) Effect of optimized precursor concentration, temperature, and doping on optical properties of ZnO nanoparticles synthesized via a green route using bush tea (Athrixia Phylicoides DC.) leaf extracts. ACS Omega 7(36):31658–31666. https://doi.org/10.1021/acsomega.2c00530
Khalafi T, Buazar F, Ghanemi K (2019) Phycosynthesis and enhanced photocatalytic activity of zinc oxide nanoparticles toward organosulfur pollutants. Sci Rep 9(1):1–10. https://doi.org/10.1038/s41598-019-43368-3
Kim JJS, Eunye K, Kyeong NY, Jong HK, Sung JP, Hu JL, So HK et al (2007) Antimicrobial effects of silver nanoparticles. Nanomed Nanotechnol Biol Med 3(1):95–101. https://doi.org/10.1016/j.nano.2006.12.001.
Kołodziejczak-radzimska A, Jesionowski T (2014) Zinc oxide—from synthesis to application: a review. Materials 7:2833–2881. https://doi.org/10.3390/ma7042833
Lakshmeesha TR, Kalagatur NK, Mudili V, Mohan CD, Rangappa S, Prasad BD, Ashwini BS et al (2019) Biofabrication of zinc oxide nanoparticles with Syzygium aromaticum flower buds extract and finding its novel application in controlling the growth and mycotoxins of Fusarium graminearum. Front Microbiol 10(June):1–13. https://doi.org/10.3389/fmicb.2019.01244
Liu J, Kang Y, Yin S, Song B, Wei L, Chen L, Shao L (2017) Zinc oxide nanoparticles induce toxic responses in human neuroblastoma SHSY5Y cells in a size-dependent manner. Int J Nanomed 12:8085–8099. https://doi.org/10.2147/IJN.S149070
Melk MM, El-Hawary SS, Melek FR, Saleh DO, Ali OM, El Raey MA, Selim NM (2021) Antiviral activity of zinc oxide nanoparticles mediated by Plumbago indica L. extract against herpes simplex virus type 1 (HSV-1). Int J Nanomed 16:8221–8233. https://doi.org/10.2147/IJN.S339404
Muhammad W, Ullah N, Haroon M, Abbasi BH (2019) Optical, morphological and biological analysis of zinc oxide nanoparticles (ZnO NPs) using: Papaver somniferum L. RSC Adv 9(51):29541–29548. https://doi.org/10.1039/c9ra04424h
Ogunyemi SO, Abdallah Y, Zhang M, Fouad H, Hong X, Ezzeldin Ibrahim Md, Masum MI, Hossain A, Mo J, Li B (2019) Green synthesis of zinc oxide nanoparticles using different plant extracts and their antibacterial activity against Xanthomonas oryzae Pv. Oryzae. Artif Cells Nanomed Biotechnol 47(1):341–352. https://doi.org/10.1080/21691401.2018.1557671
Rad SS, Sani AM, Mohseni S (2019) Biosynthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from leaf extract of Mentha pulegium (L.). Microb Pathog 131(April):239–245. https://doi.org/10.1016/j.micpath.2019.04.022
Rajeshkumar S, Venkat Kumar S, Ramaiah A, Happy A, Lakshmi T, Selvaraj MR (2018) Biosynthesis of zinc oxide nanoparticles using Mangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) Cells. Enzyme Microb Technol 117:91–95. https://doi.org/10.1016/j.enzmictec.2018.06.009
Sahu D, Kannan GM, Vijayaraghavan R (2014) Size-dependent effect of zinc oxide on toxicity and inflammatory potential of human monocytes. J Toxicol Environ Health A 77(4):177–191. https://doi.org/10.1080/15287394.2013.853224
Senthikumar N, Nandhakumar E, Priya P, Soni D, Vimalan M, Vetheher Potheher I (2017) Synthesis of ZnO nanoparticles using leaf extract of: Tectona grandis (L.) and their anti-bacterial, anti-arthritic, anti-oxidant and in vitro cytotoxicity activities. New J Chem 41(18):10347–10356. https://doi.org/10.1039/C7NJ02664A
Sirirat N, Jin-Jenn Lu, Hung A-Y, Lien T-F (2013) Effect of different levels of nanoparticles chromium picolinate supplementation on performance, egg quality, mineral retention, and tissues minerals accumulation in layer chickens. J Agric Sci 5(2):150–159. https://doi.org/10.5539/jas.v5n2p150
Soni R, Irchhaiya R, Dixit V, Shashi A (2013) Paederia foetida linn: phytochemistry, pharmacological and traditional uses.
Soni RK, Irchhaiya R, Dixit V, Alok S (2013). “Paederia Foetida Linn: phytochemistry, pharmacological and traditional uses. Int J Pharmaceutical Sci Res 4(12):4525–4530. https://doi.org/10.13040/IJPSR.0975-8232.4(12).4525-30.
Talam S, Karumuri SR, Gunnam N (2012) synthesis, characterization, and spectroscopic properties of ZnO nanoparticles. ISRN Nanotechnol 2012:1–6. https://doi.org/10.5402/2012/372505
Trang TT, Tran LT, Ha N, Ai DTT, Hien NT, Tram NTT, Huyen VT (2022) Phytochemical analysis and antioxidant and alpha-glucosidase inhibitory activities of the stem bark of Dialium Cochinchinense. Vietnam J Agric Sci 5(1):1375–1388
Wang MQ, Xu ZR (2004) Effect of chromium nanoparticle on growth performance, carcass characteristics, pork quality and tissue chromium in finishing pigs. Asian Australas J Anim Sci 17(8):1118–1122. https://doi.org/10.5713/ajas.2004.1118
Yuvakkumar R, Suresh J, Joseph Nathanael A, Sundrarajan M, Hong SI (2014) Novel green synthetic strategy to prepare ZnO nanocrystals using Rambutan (Nephelium Lappaceum L.) peel extract and its antibacterial applications. Mater Sci Eng C Mater Biol Appl 41 (August):17–27. https://doi.org/10.1016/j.msec.2014.04.025.
Zha L-Y, Zeng J-W, Chu X-W, Mao L-M, Luo H-J (2009) Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat-stressed broiler chicks. J Sci Food Agric 89(10):1782–1786. https://doi.org/10.1002/jsfa.3656
Zhu Q, Shuai X, Weidong W, Yi Q, Zhan L, Yuliang L, Yanlin Q (2022) Hierarchical hollow zinc oxide nanocomposites derived from morphology-tunable coordination polymers for enhanced solar hydrogen production. Angew Chem Int Edition 61(29):e202205312. https://doi.org/10.1002/anie.202205312.
Acknowledgements
This work was financially supported by the Project VNUA—ARESS—CCD at Vietnam National University of under Grant No. T2021-06-12VB.
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Le, T.T.H., Nguyen, T.B.T., Nguyen, T.H.H. et al. Various-sized ZnO nanoformulations synthesized with both aqueous and ethanol extracts of Paederia lanuginosa leaves. Chem. Pap. 77, 5817–5827 (2023). https://doi.org/10.1007/s11696-023-02899-w
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DOI: https://doi.org/10.1007/s11696-023-02899-w