Skip to main content
Log in

Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera

  • Original Paper
  • Published:
Chemical Papers Aims and scope Submit manuscript

Abstract

Cancer is the second foremost cause of death worldwide, and despite modern medicine development, it is needed to develop new plant-based drugs. The current study is mainly focused on the estimation of anticancerous activity of silver nanoparticles (AgNPs) fabricated by a simple and eco-friendly green approach by using leaf extract of the medicinal plant Blumea lacera (B. lacera). The prepared AgNPs were characterized by using different analytical tools. UV–visible spectra were recorded, which exhibited a sharp surface plasmonic resonance (SPR) band at 430 nm and confirmed the formation of AgNPs. The spherical morphology of synthesized AgNPs was determined with the help of field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM), and the average particle size was calculated using TEM and found to be 12.52 nm. The Fourier transformed infrared (FT-IR) spectrum of AgNPs showed characteristic bands of functional groups present in the biomolecules adsorb onto AgNPs, acting as a stabilizing agent. The crystallite nature of AgNPs formed was confirmed by the powder X-ray diffraction (PXRD) technique. The anticancerous activity of synthesized AgNPs was investigated against adherent human lung carcinoma cell A549. The minimal inhibition concentration (IC50 or MIC) value was found to be ~ 20 μg/mL for human lung carcinoma cell A549, and the result so obtained suggests that synthesized AgNPs via B. lacera possess a good ability to be used as an eco-friendly anticancerous agent. Moreover, the synthesized AgNPs possess good antioxidant activity compared to B. lacera plant leaves. The minimal inhibition concentration (IC50) of ~ 6 μg/mL for synthesized AgNPs was found.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Scheme 1
Fig. 11

Similar content being viewed by others

Abbreviations

AgNPs:

Silver nanoparticles

NPs:

Nanoparticles

B. lacera:

Blumea lacera

Fig.:

Figure

FT-IR:

Fourier transformed infrared

UV–Vis:

Ultraviolet–visible

FE-SEM:

Field emission scanning electron microscopy

DLS:

Dynamic light scattering

EDX:

Energy-dispersive X-ray spectroscopy

TEM:

Transmission electron microscopy

PXRD:

Powder X-ray diffraction

Eq.:

Equation

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide tetrazolium salt

DPPH:

2,2-Diphenylpicryl-1-hydrazyl

SPR:

Surface plasmon resonance

References

Download references

Acknowledgements

The authors are highly grateful to the Head of Department (HoD), Department of Chemistry (DoC), University of Lucknow (UoL), Lucknow (UP), India, for providing basic infrastructure facilities, like UV–visible spectrophotometry and FT-IR spectroscopy for performing experimental work for my Ph.D. degree. The authors are also thankful to Vice-Chancellor Prof. Alok Kumar Rai of Lucknow University for partially assisting with funds through the Award of Chhatra Kalyan scholarship to PP funded by University of Lucknow, India. The authors are also grateful to the Advanced Materials Research Centre (AMRC), Kamand campus, IIT Mandi, H.P, the sophisticated analytical instrumentation facility (SAIF), All India Institute of Medical Science (AIIMS), New Delhi, and Birbal Sahni institute of Palaeosciences, Lucknow, UP, India, for providing X-ray diffraction, transmission electron microscopy and field emission scanning electron microscopy facilities, respectively. The authors are indebted to the Centre of Excellence scheme, Government of Uttar Pradesh, India, for cell culture facility in Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

Authors

Contributions

All authors are equally contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Joy Sarkar.

Ethics declarations

Conflict of interest

The authors declared that there are no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pandey, P.K., Gangwar, C., Yaseen, B. et al. Anticancerous and antioxidant properties of fabricated silver nanoparticles involving bio-organic framework using medicinal plant Blumea lacera. Chem. Pap. 77, 3603–3617 (2023). https://doi.org/10.1007/s11696-023-02723-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11696-023-02723-5

Keywords

Navigation