Abstract
Calcium iodide (CaI2) catalyzes cycloaddition reaction in Nenitzescu synthesis to afford 5-hydroxyindoles from corresponding quinones and enamines. This method introduces CaI2 as a catalyst in performing this type of condensation reaction for the first time and presents advantages in using nontoxic metal, work-up simplicity, functional group tolerance, and can compete with other methods to overcome the current problems such as low yield and polymerization side reactions.
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This work was supported by the Research Council of Shahid Beheshti University of Medical Sciences.
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Teymori, A., Sedaghat, A. & Kobarfard, F. Ca-mediated Nenitzescu synthesis of 5-hydroxyindoles. Chem. Pap. 77, 1791–1795 (2023). https://doi.org/10.1007/s11696-022-02463-y
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DOI: https://doi.org/10.1007/s11696-022-02463-y