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Fe2+ activating persulfate selectively oxidized alcohols by biphasic/homogeneous reaction switch strategy

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A facile and efficient oxidation of alcohol by Fe2+ activating persulfate was performed and a homogeneous/biphasic reaction switch strategy was proposed to regulate the oxidation process. Na2S2O8 and FeSO4 were employed as the oxidant and the source of activator Fe(II), respectively. Fe2+ efficiently excited persulfate, endowing persulfate with powerful oxidation activity. Benefited from this, the oxidation of benzylic primary alcohols and cyclic secondary alcohols could proceed to give the corresponding aldehydes or ketones with good yields (85.2–98.5%) under the optimal conditions of 60 °C, 1.5 mol equivalent Na2S2O8 and 0.3 mol equivalent Fe2+ to substrate in a water/dichloroethane biphase system. Moreover, the primary alcohols were one-step oxidized into carboxylic acids with high selectivity by raising reaction temperature, increasing the amount of oxidant and switching from biphasic reaction to the water/MeCN homogeneous phase.

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Acknowledgements

This work was supported by the Natural Science Foundation of Shandong Province, China (Grant No. ZR2020KE035), Natural Science Foundation of Shandong Province, China (ZR2019MB022) and National Natural Science Foundation of China (Grant No. 21878178).

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Correspondence to Di Liu.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Wang, J., Liu, X., Wang, X. et al. Fe2+ activating persulfate selectively oxidized alcohols by biphasic/homogeneous reaction switch strategy. Chem. Pap. 76, 7229–7234 (2022). https://doi.org/10.1007/s11696-022-02366-y

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  • DOI: https://doi.org/10.1007/s11696-022-02366-y

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