Skip to main content
Log in

Fe2+ activating persulfate selectively oxidized alcohols by biphasic/homogeneous reaction switch strategy

  • Short Communication
  • Published:
Chemical Papers Aims and scope Submit manuscript


A facile and efficient oxidation of alcohol by Fe2+ activating persulfate was performed and a homogeneous/biphasic reaction switch strategy was proposed to regulate the oxidation process. Na2S2O8 and FeSO4 were employed as the oxidant and the source of activator Fe(II), respectively. Fe2+ efficiently excited persulfate, endowing persulfate with powerful oxidation activity. Benefited from this, the oxidation of benzylic primary alcohols and cyclic secondary alcohols could proceed to give the corresponding aldehydes or ketones with good yields (85.2–98.5%) under the optimal conditions of 60 °C, 1.5 mol equivalent Na2S2O8 and 0.3 mol equivalent Fe2+ to substrate in a water/dichloroethane biphase system. Moreover, the primary alcohols were one-step oxidized into carboxylic acids with high selectivity by raising reaction temperature, increasing the amount of oxidant and switching from biphasic reaction to the water/MeCN homogeneous phase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


Download references


This work was supported by the Natural Science Foundation of Shandong Province, China (Grant No. ZR2020KE035), Natural Science Foundation of Shandong Province, China (ZR2019MB022) and National Natural Science Foundation of China (Grant No. 21878178).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Di Liu.

Ethics declarations

Conflict of interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 746 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, J., Liu, X., Wang, X. et al. Fe2+ activating persulfate selectively oxidized alcohols by biphasic/homogeneous reaction switch strategy. Chem. Pap. 76, 7229–7234 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: