Abstract
Metal–organic frameworks are the new type of crystalline porous materials with specific properties such as appropriate catalytic activity, accessible surface area, tunable pore structure, as well as stable chemical and thermal properties. In this study, solvothermal preparation of a copper-metal organic framework (HKUST; Hong Kong University of Science and Technology) was used to load baclofen as a model drug. Baclofen-HKUST-1 was employed to increase the drug release controllability of bio-polymeric carboxymethyl cellulose (CMC) hydrogel under the gastrointestinal tract (GIT). Results from in vitro drug delivery and kinetic assessments revealed that CMC/baclofen-HKUST-1 bio-nanocomposite could better act against stomach pH; it also increased the releasing homogeneity and drug delivery under GIT conditions. Also, MTT assay demonstrated there was considerable cytotoxicity against human colon cells associated with CMC/baclofen-HKUST-1 bio-nanocomposite. According to the findings of CMC/baclofen-HKUST-1 bio-nanocomposite assessments, the mentioned component could be applied to drug administration.
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We gratefully acknowledge financial support from the National Natural Science Foundation of China (Grant No.: 22050410269).
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HN was in charge of the experimental implementation, data analysis, and writing of the original draft. MM and YH revised the manuscript.
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Nabipour, H., Mansoorianfar, M. & Hu, Y. Carboxymethyl cellulose-coated HKUST-1 for baclofen drug delivery in vitro. Chem. Pap. 76, 6557–6566 (2022). https://doi.org/10.1007/s11696-022-02348-0
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DOI: https://doi.org/10.1007/s11696-022-02348-0