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Microwave synthesis of zinc-trimesic acid metal–organic framework for visual fluorescence detection of tetracyclines

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The excessive use of antibiotics in agriculture leads to their contamination in food and water; it is highly demanded to develop new functional materials for their fast and on-site detection. In this paper, we synthesized a zinc(II)-trimesic acid metal–organic framework (Zn-BTC) by microwave and explored its practical application for the detection of chlortetracycline (CTC) based on conformational variation mechanism. A limit of detection (LOD) of 24 nM was estimated for CTC according to the 3σ principle. Due to their similar unique structural properties, other tetracyclines also produce fluorescence enhancement upon adsorption with Zn-BTC, which can be used to distinguish tetracyclines from other antibiotics. Based on the properties, a test paper was fabricated by loading Zn-BTC on glass fiber filter paper. The paper could be used for non-contact visual detection of CTC, suggesting great application potential in water quality monitoring.

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We acknowledge the financial support from the National Natural Science Foundation of China (21775042 and 22176044), the National Key Research and Development Program of China (2017YFA0207003), and Projects of Talents Recruitment of GDUPT (2019rc056 and 2019rc057).

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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Songlin Zhang, Long Yu, Pengchen Su, and Hongwei Ge. The first draft of the manuscript was written by Songlin Zhang and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ming-Tai Sun or Su-Hua Wang.

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Zhang, SL., Yu, L., Su, PC. et al. Microwave synthesis of zinc-trimesic acid metal–organic framework for visual fluorescence detection of tetracyclines. Chem. Pap. 76, 4777–4786 (2022).

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