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Eco-friendly synthesis and characterizations of Ag/AgO/Ag2O nanoparticles using leaf extracts of Solanum elaeagnifolium for antioxidant, anticancer, and DNA cleavage activities

Chemical Papers volume 76, pages 4309–4321 (2022)Cite this article

Abstract

The biogenic synthesis of nanoparticles (NPs) using a plant extract is rapid, simple, efficient, cost-effective, and eco-friendly. This study investigated selective pharmacological activities such as anticancer, antioxidant, and DNA cleavage of S. elaeagnifolium-mediated green synthesizing Ag/AgO/Ag2O NPs. To the best of our knowledge, S. elaeagnifolium has been the first time used to synthesize Ag/AgO/Ag2O NPs. The synthesized NPs were explored by using UV–Vis diffuse reflectance spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy, energy-dispersive X-ray spectroscopy, and photoluminescence analyses. Anticancer activity of Ag/AgO/Ag2O NPs was tested on lung cancer cell lines (A-549) and showed activity at the IC50 of 67.09 μg/mL. The maximum 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity were 25.78% and 20.86% at 100 µg/L, respectively. Moreover, S. elaeagnifolium-mediated green synthesized Ag/AgO/Ag2O NPs exhibited considerable DNA cleavage activity. These results assured that the synthesized Ag/AgO/Ag2O NPs using S. elaeagnifolium leaves extract may have potential applications in biomedical engineering.

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Abbreviations

Ag:

Silver

DFT:

Density functional theory

DMSO:

Dimethyl sulphoxide

DNA:

Deoxyribonucleic acid

EDTA:

Ethylenediamine tetraacetic acid

EDX:

Energy-dispersive X-ray spectroscopy

FTLR:

Fourier transform infrared spectroscopy

HRTEM:

High-resolution transmission electron microscopy

IC50 :

Half maximal inhibitory concentration

MTT:

3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide

NPs:

Nanoparticles

PL:

Photoluminescence

SAED:

Selected area electron diffraction

SELE:

Solanum elaeagnifolium Leaves extract

SEM:

Scanning electron microscopy

UVDRS:

UV–Vis diffuse reflectance spectroscopy

XRD:

X-ray diffraction

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Acknowledgements

This work was supported by the Distinguished Scientist Fellowship Program (DSFP) at King Saud University, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Chemistry, Sanjivani Arts, Commerce and Science College, Savitribai Phule Pune University, Kopargaon, Maharashtra, 423603, India

    Mukul Barwant & Yogrsh Ugale

  2. Department of Chemistry, Smt. Devkiba Mohansinhji Chauhan College of Commerce and Science, University of Mumbai, Silvassa, Dadra and Nagar Haveli (UT), 396230, India

    Suresh Ghotekar

  3. Centre for Materials Science and Nanotechnology, Sikkim Manipal Institute of Technology, Sikkim Manipal University, Gangtok, Sikkim, India

    Parita Basnet

  4. Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, Tamilnadu, 603 103, India

    Van-Huy Nguyen

  5. Department of Chemistry, Shri Saibaba College Shirdi, Savitribai Phule Pune University, Shirdi, Maharashtra, 423109, India

    Shreyas Pansambal

  6. Department of Applied Chemistry, School of Applied Natural Sciences, Adama Science and Technology University, P.O. Box: 1888, Adama, Ethiopia

    H. C. Ananda Murthy

  7. Department of Chemical Engineering, School of Mining, Metallurgy and Chemical Engineering, University of Johannesburg, P. O. Box 17011, Doornfontein, 2028, South Africa

    Mika Sillanpaa

  8. Chemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Mika Sillanpaa

  9. School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, 223003, China

    Muhammad Bilal

  10. Department of Chemistry, D.J.M. Commerce and B.N.S. Science College, Savitribai Phule Pune University, S.N. Arts, Sangamner, Maharashtra, 422605, India

    Rajeshwari Oza

  11. Department of Botany, Yashavantrao Chavan Institute of Science, Satara, Maharashtra, 415001, India

    Vanita Karande

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  1. Mukul Barwant
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  2. Yogrsh Ugale
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  4. Parita Basnet
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Correspondence to Suresh Ghotekar.

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Barwant, M., Ugale, Y., Ghotekar, S. et al. Eco-friendly synthesis and characterizations of Ag/AgO/Ag2O nanoparticles using leaf extracts of Solanum elaeagnifolium for antioxidant, anticancer, and DNA cleavage activities. Chem. Pap. 76, 4309–4321 (2022). https://doi.org/10.1007/s11696-022-02178-0

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Keywords

  • Green nanotechnology
  • Solanum elaeagnifolium
  • Ag/AgO/Ag2O NPs
  • Biomedical applications