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Synthesis, theoretical and experimental spectroscopic properties, molecular docking, ADMET, and RDG analysis of copper(II) complex of dichloro(1,10-phenanthroline)(1,2,4-triazole-3-carboxcylic acid)

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A new dichloro(1,10-phenanthroline)(1,2,4-triazole-3-carboxylic-acid)copper(II) was synthesized, and the most stable optimized structure was determined using the B3LYP/LANL2DZ basis set, followed by FTIR and NMR characterization. The molecular geometric structure analysis and vibrational frequencies of the Cu(II) complex were calculated by using density functional theory calculations in the ground state. Metal-ligand and intra-ligand vibrations were investigated using vibrational analysis, and the obtained computational values were compared with the experimental values. The ProTox-II webserver was utilized for toxicological evaluation of the organism and organ, as well as molecular mechanisms of toxicity evidenced by the median lethal dose (LD50). SwissADME prediction was performed ADMET properties. Reduced density gradient (RDG) analysis is employed to study the weak interactions within the molecule. The nature of the chemical bonds in the [Cu(phen)(TCA)2Cl2] complex is investigated using electron localization function (ELF) analysis. MEPs, HOMO, LUMO, global reactivity descriptors, and Fukui functions are performed to study the chemical reactivity of the compound. Molecular docking studies are performed to predict the antibacterial, antidepressant, and anti-anxiety active site of the complex. Cu(phen)(TCA)2Cl2 was defined and used to evaluate the antibacterial properties of this Cu(II) complex against B. subtilis.

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The authors are thankful to Belgin ERDEM (Kırşehir Ahi Evran University) for the antibacterial activity part of the manuscript.


This research received no external funding.

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Material preparation, data collection, and analysis were performed by SC, SB, and ŞY. The software and formal analysis was performed by SC. Writing—review and editing of the manuscript was done by SC, SB, and ŞY. All authors commented on previous versions of the manuscript. All authors contributed to the study conception and design and approved the final manuscript.

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Correspondence to Sibel Celik.

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Celik, S., Badoğlu, S. & Yurdakul, S. Synthesis, theoretical and experimental spectroscopic properties, molecular docking, ADMET, and RDG analysis of copper(II) complex of dichloro(1,10-phenanthroline)(1,2,4-triazole-3-carboxcylic acid). Chem. Pap. 76, 4099–4114 (2022).

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