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Impacts of channel wall twisting on the mixing enhancement of a novel spiral micromixer

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A Correction to this article was published on 21 October 2021

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Micromixer is one of the most widely used components in microfluidic systems to homogenize species or reactants in medical diagnostic processes, DNA, biochemistry, chemical processes, etc. Achieving fast and efficient mixing has always been difficult due to the difficulty of mass transfer in the laminar flow regime. In the present study, a novel micromixer is proposed using the simultaneous impacts of twisted wall and plane spiral microchannel, making the mixer to be efficient at low and high Reynolds numbers. The present simulations are performed using the finite difference method and ANSYS FLUENT 2021 software. It is shown that for a given Reynolds number, the mixing efficiency of the proposed micromixer is 53% higher than that of a T-shaped twisted microchannel and 51% higher than that of a plane spiral one. The mixing efficiency of a ¾ loop of the twisted-spiral microchannel is 7.51% higher than one and a half loops of a plane spiral channel. The proposed microchannel provides a 35% improvement in the mixing quality while the pressure drop is enhanced by less than 0.5%.

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  • Ahmadi VE et al (2021) The effects of baffle configuration and number on inertial mixing in a curved serpentine micromixer: experimental and numerical study. Chem Eng Res Des 168:490–498

    Article  CAS  Google Scholar 

  • Akar S et al (2021) Twisted architecture for enhancement of passive micromixing in a wide range of Reynolds numbers. Chem Eng Process-Process Intensification. 160:108251

    Article  CAS  Google Scholar 

  • Bahrami D, Nadooshan AA, Bayareh M (2020) Numerical study on the effect of planar normal and Halbach magnet arrays on micromixing. Int J Chem Reactor Eng.

    Article  Google Scholar 

  • Balasubramaniam L et al (2017) Impact of cross-sectional geometry on mixing performance of spiral microfluidic channels characterized by swirling strength of Dean-vortices. J Micromech Microeng 27(9):095016

    Article  Google Scholar 

  • Bayareh M, Ashani MN, Usefian A (2020) Active and passive micromixers: a comprehensive review. Chem Eng Process-Process Intensification 147:107771

    Article  CAS  Google Scholar 

  • Hadjigeorgiou AG, Boudouvis AG, Kokkoris G (2021) Thorough computational analysis of the staggered herringbone micromixer reveals transport mechanisms and enables mixing efficiency-based improved design. Chem Eng J 414:128775

    Article  CAS  Google Scholar 

  • Kang DJ (2020) Effects of channel wall twisting on the mixing in a T-shaped micro-channel. Micromachines 11(1):26

    Article  Google Scholar 

  • Kharaji, Z.G., M. Bayareh, and V. Kalantar, (2021) A review on acoustic field-driven micromixers. Int J Chem Reactor Eng,

  • Mashaei P, Asiaei S, Hosseinalipour S (2020) Mixing efficiency enhancement by a modified curved micromixer: a numerical study. Chem Eng Process-Process Intensification 154:108006

    Article  CAS  Google Scholar 

  • Puneeth S, Kulkarni MB, Goel SG (2021) Microfluidic viscometers for biochemical and biomedical applications: a review. Eng Res Exp 3:022033

    Google Scholar 

  • Rajbanshi P, Ghatak A (2020) Analysis of mixing in a helical microchannel. Phys Rev Fluid. 5(6):064502

    Article  Google Scholar 

  • Rashidi S et al (2018) A review on the application, simulation, and experiment of the electrokinetic mixers. Chem Eng Process-Process Intensification 126:108–122

    Article  CAS  Google Scholar 

  • Stoller M, Di Palma L, Vuppala S, Verdone N, Vilardi G (2021) Process intensification techniques for the production of nano- and submicronic particles for food and medical applications. Curr Pharm Des 27:2329–2338

    Google Scholar 

  • Tachibana D et al (2020) 3D helical micromixer fabricated by micro lost-wax casting. Adv Mater Technol 5(1):1900794

    Article  CAS  Google Scholar 

  • Talebjedi B et al (2021) Performance optimization of a novel passive T-shaped micromixer with deformable baffles. Chem Eng Process-Process Intensification 163:108369

    Article  CAS  Google Scholar 

  • Tripathi E, Patowari PK, Pati S (2021) Comparative assessment of mixing characteristics and pressure drop in spiral and serpentine micromixers. Chem Eng Process-Process Intensification 162:108335

    Article  CAS  Google Scholar 

  • Usefian A, Bayareh M (2019) Numerical and experimental study on mixing performance of a novel electro-osmotic micro-mixer. Meccanica. 54(8):1149–1162

    Article  Google Scholar 

  • Usefian A, Bayareh M, Nadooshan AA (2019) Rapid mixing of Newtonian and non-Newtonian fluids in a three-dimensional micro-mixer using non-uniform magnetic field. J Heat and Mass Trans Res 6(1):55–61

    Google Scholar 

  • Vatankhah P, Shamloo A (2018) Parametric study on mixing process in an in-plane spiral micromixer utilizing chaotic advection. Anal Chim Acta 1022:96–105

    Article  CAS  Google Scholar 

  • Vilardi G, Verdone N (2020) Production of metallic iron nanoparticles in a baffled stirred tank reactor: optimization via computational fluid dynamics simulation. Particuology.

    Article  Google Scholar 

  • Vilardi G, Stoller M, Di Palma L, Boodhoo K, Verdone N (2019) Metallic iron nanoparticles intensified production by Spinning Disk Reactor: optimization and fluid dynamics modelling. Chem Eng Process - Process Intensification.

    Article  Google Scholar 

  • Vilardi G, De Caprariis B, Stoller M, Di Palma L, Verdone N (2020) Intensified water denitrification by means of a spinning disk reactor and stirred tank in series: kinetic modelling and computational fluid dynamics. J Water Process Eng 34:101147.

    Article  Google Scholar 

  • Vilardi G, Verdone N, Bubbico R (2021) Combined production of metallic-iron nanoparticles: exergy and energy analysis of two alternative processes using Hydrazine and NaBH4 as reducing agents. J Taiwan Inst Chem Eng 118:97–111

    Article  CAS  Google Scholar 

  • Wang X et al (2021) A cost-effective serpentine micromixer utilizing ellipse curve. Analytica Chimica Acta 1155:338355

    Article  CAS  Google Scholar 

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Correspondence to Morteza Bayareh.

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The original Online version of this article was revised : The figures Fig. 5 (a) and Fig. 10 (C) has been incorrectly published.

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Bahrami, D., Bayareh, M. Impacts of channel wall twisting on the mixing enhancement of a novel spiral micromixer. Chem. Pap. 76, 465–476 (2022).

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