Skip to main content

pH-controlled new mixed-ligand coordination polymers: luminescent properties and promotion activity on the children bone growth and development


Through precisely adjusting the pH value of reaction system, two new mixed-ligand based coordination polymers, namely [Zn(ip)0.5(bta)]n (1) and [Zn3(Hip)4(bta)2]n (2) (H2ip = isophthalic acid, Hbta = benzotriazole), have been acquired through the self-assemble reaction of Zn(II) salts in combination with H2ip and Hbta. Both compounds have high thermal stability demonstrated by the thermogravimetric analysis (TGA) experiments, and exhibit strong luminescence emission at room temperature. Their application values on the children bone growth and development were evaluated and the specific mechanism was examined simultaneously. Above all, compound 1 was more outstanding than compound 2 against the children bone growth and development by regulating the Vitamin K receptor on the bone cell surface.

Graphic abstract

This is a preview of subscription content, access via your institution.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Data availability

Selected bond lengths (Å) and angles (°) of compounds 12 (Table S1); PXRD patterns (a) for compound 1 and (b) for compound 2 (Fig. S1); The FT-IR spectra of CPs 1 and 2 (Fig. S2), the information could be found in the supporting information file.


  1. Bai Y, Zhang B, Du H, Cheng L (2021) Efficient multiscale strategy for toughening HfB2 ceramics: A. heterogeneous ceramic–metal layered architecture. J Am Ceram Soc 104:1841–1851.

    CAS  Article  Google Scholar 

  2. Diamantopoulou E, Raptopoulou CP, Terzis A, Tangoulis V, Perlepes SP (2002) Heptanuclearity in nickel(II). chemistry: preparation, characterization, crystal structure and magnetic properties of [Ni7(OH)2(acac)8(btaO)4(H2O)2] (btaO=the 1-hydroxybenzotriazolate ion). Polyhedron 21:2117–2126.

    CAS  Article  Google Scholar 

  3. Duan C, Yu Y, Li J, Li L, Huang B, Chen D, Xi H (2021) Recent advances in the synthesis of monolithic metal-organic frameworks. Sci China Mater 64:1305–1319.

    CAS  Article  Google Scholar 

  4. Feng X, Feng YQ, Liu L, Wang LY, Song HL, Ng SW (2013a) A series of Zn-4f heterometallic coordination polymers and a zinc complex containing a flexible mixed donor dicarboxylate ligand. Dalt Trans 42:7741–7754.

    CAS  Article  Google Scholar 

  5. Feng X, Ma LF, Liu L, Xie SY, Wang LY (2013b) A series of heterometallic three dimensional frameworks constructed from imidazole dicarboxylate: structures, luminescence and magnetic property. Cryst Growth Des 13:4469–4479.

    CAS  Article  Google Scholar 

  6. Gu JZ, Liang XX, Cai Y, Wu J, Shi ZF, Kirillov AM (2017) Hydrothermal assembly, structures, topologies, luminescence, and magnetism of a novel series of coordination polymers driven by a trifunctional nicotinic acid building block. Dalt Trans 46:10908–10925.

    CAS  Article  Google Scholar 

  7. Hu ML, Abbasi-Azad M, Habibi B, Rouhani F, Moghanni-Bavil-Olyaei H, Liu KG, Morsali A (2020a) Electrochemical applications of ferrocene-based coordination polymer. ChemPlusChem 85:2397–2418.

    CAS  Article  PubMed  Google Scholar 

  8. Hu ML, Razavi SA, Piroozzadeh M, Morsali A (2020b) Sensing organic analytes by Metal-organic frameworks: a. new way of considering the topic. Inorg Chem Front 7:1598–1632.

    CAS  Article  Google Scholar 

  9. Huang YY, Zhang X, Yao YG (2013) Employing heterometallic trinuclear cluster as building subunit to construct. A new coordination polymer with rare 3D inorganic -Cd-O-Ba- connectivity. Inorg Chim Acta 397:38–41.

    CAS  Article  Google Scholar 

  10. Huang W, Jiang J, Wu D, Xu J, Xue B, Kirillov AM (2015) A Highly stable nanotubular MOF rotator for. Selective adsorption of benzene and separation of xylene isomers. Inorg Chem 54:10524–10526.

    CAS  Article  PubMed  Google Scholar 

  11. Jaros SW, Sokolnicki J, Wołoszyn A, Haukka M, Kirillov AM, Smoleński P (2018) A novel 2D coordination. network built from hexacopper(i)-iodide clusters and cagelike aminophosphine blocks for reversible “turn-on” sensing of aniline. J Mater Chem C 6:1670–1678.

    CAS  Article  Google Scholar 

  12. Kim K, Lee S, Jin E, Palanikumar L, Lee JH, Kim JC, Nam JS, Jana B, Kwon TH, Kwak SK, Choe W, Ryu JH (2019) MOF×biopolymer: collaborative combination of metal-organic framework and biopolymer for advanced anticancer therapy. ACS Appl Mater Inter 11:27512–27520.

    CAS  Article  Google Scholar 

  13. Klentrou P (2016) Influence of exercise and training on critical stages of bone growth and development. Pediatr Exerc Sci 28:178–186.

    Article  PubMed  Google Scholar 

  14. Li JX, Du ZX, Zhang LL, Liu DL, Pan QY (2020) Doubly mononuclear cocrystal and oxalato-bridged binuclear. copper compounds containing flexible 2-((3,5,6-trichloropyridin-2-yl)oxy)acetate tectons: Synthesis, crystal analysis and magnetic properties. Inorg Chim Acta 512:119890.

    CAS  Article  Google Scholar 

  15. Li JX, Du ZX, Xiong LY, Fu LL, Bo WB (2021) Supramolecular isomerism in two nickel(II) coordination. polymers constructed with the flexible 2-carboxyphenoxyacetate linker: Syntheses, structure analyses and magnetic properties. J Solid State Chem 293:121799.

    CAS  Article  Google Scholar 

  16. Liu KG, Gao XM, Liu T, Hu ML, Jiang DN (2020) All-Carboxylate-Protected Superatomic Silver Nanocluster. with an Unprecedented Rhombohedral Ag8 Core. J Am Chem Soc 142:16905–16909.

    CAS  Article  PubMed  Google Scholar 

  17. Lu J, Zhao K, Fang QR, Xu JQ, Yu JH, Zhang X, Bie HY, Wang TG (2005) Synthesis and characterization of four. novel supramolecular compounds based on metal zinc and cadmium. Cryst Growth Des 5:1091–1098.

    CAS  Article  Google Scholar 

  18. Prentice A, Schoenmakers I, Laskey MA, de Bono S, Ginty F, Goldberg GR (2006) Nutrition. and bone growth and development. Proc Nutr Soc 65:348–360.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  19. Qin YY, Zhang X, Shen YC, Yao YG (2015) A novel luminescent zinc(II) coordination polymer with 2D→3D. polythreaded motif. Chin J Struct Chem 34:1399–1404.

    CAS  Article  Google Scholar 

  20. Rybak JC, Müller-Buschbaum K (2010) The benzotriazolate coordination polymer [Eu(Btz)2(BtzH)2], Containing Divalent Europium. Z Anorg Allg Chem 636:126–131.

    CAS  Article  Google Scholar 

  21. Sanati S, Abazari R, Morsali A, Kirillov AM, Junk PC, Wang J (2019) An asymmetric supercapacitor based on a. Non-calcined 3D pillared cobalt(II) metal-organic framework with long cyclic stability. Inorg Chem 58:16100–16111.

    CAS  Article  PubMed  Google Scholar 

  22. Sheldrick GM (2015) Crystal structure refinement with SHELXL. Acta Crystallogr Sect c: Struct Chem 71:3–8.

    CAS  Article  Google Scholar 

  23. Xu H, Du H, Kang L, Cheng Q, Feng D, Xia S (2021) Constructing straight pores and improving mechanical. Properties of Gangue Based Porous Ceramics. J Renew Mater 9:2129–2141.

    Article  Google Scholar 

  24. Xue X, Li GT, Peng YH, Wu L, Wu BL (2011) Two photoluminescent pentanuclear homo- and hetero-metal. complexes based on benzotriazole bridge. J Coord Chem 64:1953–1962.

    CAS  Article  Google Scholar 

  25. Zhang Q, Jiang X, Kirillov AM, Zhang Y, Hu M, Liu W, Yang L, Fang R, Liu W (2019) Covalent construction. of sustainable hybrid UiO-66-NH2@Tb-CP material for selective removal of dyes and detection of metal ions. ACS Sustain Chem Eng 7:3203–3212.

    CAS  Article  Google Scholar 

  26. Zhang X, Qin YY, Sun ML, Yao YG (2016) A Zn(II) coordination polymer with 4-connected bbf topology: synthesis, crystal structure and luminescent property. Chin J Struct Chem 35:1145–1150.

    CAS  Article  Google Scholar 

  27. Zhao SQ, Gu JZ (2021a) Syntheses, structures and catalytic properties of two Mn(II) and Cd(II) coordination. polymers through in situ ligand reaction. Chin J Struct Chem 40:785–796.

    CAS  Article  Google Scholar 

  28. Zhao SQ, Gu JZ (2021b) Synthesis, structure and catalytic properties of Mn(II) coordination polymers through in. situ ligand reaction. Chin J Inorg Chem 37:751–757.

    Article  Google Scholar 

  29. Zhao Y, Li K, Li J (2010) Review. Solvothermal synthesis of multifunctional coordination polymers. Zeitschrift Für Naturforsch B 65:976–998.

    CAS  Article  Google Scholar 

  30. Zhuge J, Rouhani F, Bigdeli F, Gao XM, Kaviani H, Li HJ, Wang W, Hu ML, Liu KG, Morsali A (2021) Stable. supercapacitor electrode based on two-dimensional high nucleus silver nano-clusters as a green energy source. Dalton Trans 50:2606–2615.

    CAS  Article  PubMed  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to De-Guang Liu.

Ethics declarations

Conflicts of interest

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOC 1831 KB)

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jiang, P., Liu, XQ., Sun, AL. et al. pH-controlled new mixed-ligand coordination polymers: luminescent properties and promotion activity on the children bone growth and development. Chem. Pap. (2021).

Download citation


  • Zn(II) compound
  • Luminescence
  • Bone growth and development