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Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.

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Abstract

Elaeocarpus hygrophilus Kurz. is a tropical tree that has recently been used for food and medicinal purposes. This study aimed to reveal the phytochemicals and evaluate the anti-influenza viral and neuroprotective effects of different parts of this plant including leaves, stems, fruit peels, and seeds. The study results indicated that the leaf extract was a potential candidate in the inhibition of the influenza viral replication through anti-neuraminidase receptors and attenuation of the glutamate-induced neuronal cell death and cellular oxidative stress. Using molecular networking as well as fragmentation, twenty-six known compounds were dereplicated from the leaves of E. hygrophilus. Molecular docking simulations of target proteins (PDB: 3CL0 and 4CXT) with these predicted compounds indicated that phenolic compounds from the EtOH leaf extract may be considered as active components for treating not only neuraminidase inhibitor-resistant strains but also activating Keap1/Nrf2 pathway. The anti-influenza viral and neuroprotective effects of the leaf extract and the link between the two activities could significantly contribute to the development of natural product drugs for influenza treatment and prevention of neuropsychiatric adverse events. These results suggested further research about the phytochemicals and the bio-guided isolation of the most active fractions from the leaf extract and their respective herbal drug formulations, with effective and secure aspects, to low-income populations of the tropics.

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Funding

This work was supported by the Scientific research fund of Can Tho University (T2020-24). We are especially thankful to Prof. Won Keun Oh, Dr. Ba Wool Lee, and Dr. Byeol Ryu (Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) for supporting HRESI-qTOF MS/MS and biology experiments. We would also like to extend my thanks to Dr. Eunhee Kim (Choong Ang Vaccine Laboratory, 59-3 Hwaam-dong, Yuseong-gu, Daejeon 305-348, Republic of Korea) for purified and provided virus stocks of the influenza viruses.

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TKQH performed the biological experiments, docking studies, and wrote the manuscript. TPD, HTTP, and NHN carried out the plant extraction and HRESI-qTOF MS/MS procedure and MS/MS molecular networking. TTN and HTTP collected the plant samples. TBHB supported the data analysis. TKQH designed the research and was also the corresponding author. The manuscript was reviewed by all authors.

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Correspondence to Thi Kim Quy Ha.

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Ha, T.K.Q., Doan, T.P., Pham, H.T.T. et al. Molecular networking-based chemical profiling and anti-influenza viral and neuroprotective effects of Elaeocarpus hygrophilus Kurz.. Chem. Pap. 75, 5323–5337 (2021). https://doi.org/10.1007/s11696-021-01723-7

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  • DOI: https://doi.org/10.1007/s11696-021-01723-7

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