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Derivation of adsorption capacity and adsorption isotherm by a single adsorbate concentration in liquid–solid system

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A novel approach was presented as a strategy for deriving adsorption capacity and isotherm by a single adsorbate concentration in the liquid–solid system with experimental proof utilizing frontal chromatography (FC). A breakthrough curve equation presented in this work shows the dependence of adsorbate concentration in feed solution on time in FC and can be used to derive three characteristic binding parameters n (the number of the adsorbates bound to adsorbents), K (the adsorption equilibrium constant of adsorbates) and na (the total number of the adsorption sites). Moreover, the adsorption capacity and isotherm could be derived by a single breakthrough curve, even part of it. The equation was verified with the breakthrough curves of some arene and proteins on reversed-phase, ion-exchange, hydrophobic and affinity media, showing good fitness and consistent with the classical static method and elution peak method. Besides, all the adsorption data were referred to the type I adsorption of the Langmuir isotherm. This work presented new insight that utilizing a single breakthrough curve to determine adsorption parameters and isotherms and may provide some perspective for the determination of physico-chemical property and performance study of very rare substances.

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We sincerely acknowledge the financial supported by National Natural Science Foundation of China (nos. 31971143, 21075097)

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Correspondence to Liujiao Bian.

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Zhang, J., Bai, J., Duan, M. et al. Derivation of adsorption capacity and adsorption isotherm by a single adsorbate concentration in liquid–solid system. Chem. Pap. 75, 2459–2476 (2021).

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