Abstract
A poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode (p-ABSA/GCE) was fabricated by electropolymerization. It was found that phentolamine mesylate, an effective and important cardiovascular dilatation drug with low redox activity at the glassy carbon electrode (GCE) can produce a sensitive well-defined anodic peak current at p-ABSA/GCE. Investigation indicated that the oxidation of phentolamine at p-ABSA/GCE was one electron/one proton transfer process which was controlled by adsorption. In optimal conditions, the anodic peak current was linear to the concentrations of phentolamine over the range of 5.0 × 10–7–1.0 × 10–5 M with a detection limit of 2.0 × 10–7 M. The modified electrode showed good stability and reproducibility. The electroanalytical method proposed was successfully applied to the determination of phentolamine mesylate in pharmaceutical formulations.
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The authors thank senior professor Wei Ding (Polymer Institute of Northeast Petroleum University) for his help and useful discussions.
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Fan, S., Ji, L., Mao, G. et al. Voltammetric determination of phentolamine mesylate in pharmaceutical formulations at poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode. Chem. Pap. 74, 4411–4417 (2020). https://doi.org/10.1007/s11696-020-01250-x
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DOI: https://doi.org/10.1007/s11696-020-01250-x