Skip to main content
Log in

One-pot green synthesis of l-proline-stabilized copper nanoclusters for quercetin sensing

  • Original Paper
  • Published:
Chemical Papers Aims and scope Submit manuscript


Herein, a simple, green and low-cost method was established to synthesize l-proline-stabilized copper nanoclusters (l-Pro-Cu NCs) with good water solubility, excellent photostability and resistance to sodium chloride. A series of methods including fluorescence spectroscopy, UV–Vis absorption spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy and X-ray photoelectron spectroscopy were used to characterize the structure and optical performance of the Cu NCs. The as-prepared Cu NCs showed green fluorescence with the excitation wavelength of 373 nm. Under the optimal detection conditions, an excellent linear relationship was observed between relative fluorescence intensity (F0/F) and the concentrations of quercetin ranging from 0.5 to 50 μM, and the detection limit (LOD) was 0.012 μM. Moreover, the proposed method provided an excellent platform for the detection of quercetin in the real samples.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others


Download references


This work was supported by the Shanxi Applied Basic Research Project (Grant No. 201801D121257), the Shanxi Province Science Foundation for Youths (Grant No. 201801D221142) and the Fund for Shanxi “1331 Project” Collaborative Innovation Center (Grant No. I018038).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Zhifeng Cai.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cai, Z., Zhu, R., Zhang, C. et al. One-pot green synthesis of l-proline-stabilized copper nanoclusters for quercetin sensing. Chem. Pap. 74, 3839–3846 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: