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Graphene oxide nanoribbon catalysis of gold nanoreaction and its application to SERS quantitative analysis of ultratrace glucose

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Catalysis of four nanostructures, including graphene oxide nanoribbons (GONR), graphene oxide, N-doped carbon quantum dot and Ca-doped carbon quantum dot is examined on the reaction HAuCl4–trisodium citrate to form nanogold (AuNP). GONR exhibited strongest catalysis and appeared a SERS peak at 1615 cm−1 in the presence of Victoria blue 4R molecular probes in the formed AuNP sol substrate. Upon addition of 4-mercaptophenylboronic acid (MPBA), it adsorbs on GONR to form MPBA–GONR conjugates that caused the SERS peak decreasing due to its catalysis decreasing. Upon addition of glucose, it reacts with MPBA to form MPBA–glucose complex to increase the SERS peak linearly owing to GONR catalysis recovering. The increased SERS signal (ΔI) is linear to glucose concentration in the range of 0.33–5.33 nM, with a detection limit of 0.13 nM. Thus, a new and highly sensitive SERS quantitative analysis method is established for detection of glucose, based on GONR catalytic amplification.

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Surface-enhanced Raman scattering


Resonance Rayleigh scattering


Scanning electron microscopy


Graphene oxide nanoribbons


Graphene oxide


N-doped carbon quantum dot

CDCa :

Ca-doped carbon quantum dot


Trisodium citrate




Victoria blue 4R


4-Mercaptophenylboronic acid


  • Araujo A, Caro C, Mendes MJ, Nunes D, Fortunato E, Franco R, Águas H, Martins R (2014) Highly efficient nanoplasmonic SERS on cardboard packaging substrates. Nanotechnology 25:415202–415210

    Article  Google Scholar 

  • Botta R, Rajanikanth A, Bansal C (2016) Silver nanocluster films for glucose sensing by Surface Enhanced Raman scattering (SERS). Sens Bio-Sens Res 9:13–16

    Article  Google Scholar 

  • Caro C, Sayagues MJ, Franco V, Conde A, Zaderenko P, Gamez F (2016) A hybrid silver-magnetite detector based on surface enhanced Raman scattering for differentiating organic compounds. Sens Actuators B 228:124–133

    Article  CAS  Google Scholar 

  • Chen QL, Fu Y, Zhang WH, Ye SB, Zhang H, Xie FY, Gong L, Wei ZX, Jin HY, Chen J (2017) Highly sensitive detection of glucose: a quantitative approach employing nanorods assembled plasmonic substrate. Talanta 165:516–521

    Article  CAS  Google Scholar 

  • Daniel M, Javier C, José LGF, Francisco JGA, Agustín C (2017) Copper-modified titanium phosphate nanoparticles as electrocatalyst for glucose detection. Electrochim Acta 229:102–111

    Article  Google Scholar 

  • Fu CC, Jin SL, Oh J, Xu SP, Jung Y (2017) Facile detection of glucose in human serum employing silver-ion-guided surface-enhanced Raman spectroscopy signal amplification. Analyst 142:2887–2891

    Article  CAS  Google Scholar 

  • Huang NJ, Zang J, Zhang GD, Guan LZ, Li SN, Zhao L, Tang LC (2017a) Efficient interfacial interaction for improving mechanical properties of polydimethylsiloxane nanocomposites filled with low content of graphene oxide nanoribbons. RSC Adv 7:22045–22053

    Article  CAS  Google Scholar 

  • Huang Z, Cao G, Sun Y, Du S, Li Y, Feng S, Lin J, Lei J (2017b) Evaluation and optimization of paper-based SERS substrate for potential label-free Raman analysis of seminal plasma. J Nanomaterials 2017:4807064

    Google Scholar 

  • Jiang JJ, Chen D, Du XZ (2017) Ratiometric electrochemiluminescence sensing platform for sensitive glucose detection based on in situ generation and conversion of coreactants. Sens Actuators B 251:256–263

    Article  CAS  Google Scholar 

  • Jin LH, Meng Z, Zhang YQ, Cai SJ, Zhang ZH, Li C, Shang L, Shen YH (2017) Ultrasmall Pt nanoclusters as robust peroxidase mimics for colorimetric detection of glucose in human serum. ACS Appl Mater Interfaces 9:10027–10033

    Article  CAS  Google Scholar 

  • Jose MGD, Andrea C, Lucio L, Adrian O, Moreno M, Tatiana DR (2019) Thiolated graphene oxide nanoribbons as templates for anchoring gold nanoparticles: two-dimensional nanostructures for SERS. ChemPlusChem 84:862–871

    Article  Google Scholar 

  • Krishnan SK, Prokhorov E, Bahena D, Esparza R, Meyyappan M (2017) Chitosan-covered Pd@Pt core–shell nanocubes for direct electron transfer in electrochemical enzymatic glucose biosensor. ACS Omega 2:1896–1904

    Article  CAS  Google Scholar 

  • Li YQ, Sun L, Qian J, Long LL, Li HN, Liu Q, Cai JR, Wang K (2017) Fluorescent “on-off-on” switching sensor based on CdTe quantum dots coupled with multiwalled carbon nanotubes@graphene oxide nanoribbons for simultaneous monitoring of dual foreign DNAs in transgenic soybean. Biosens Bioelectron 92:26–32

    Article  CAS  Google Scholar 

  • Li CN, Fan PD, Liang AH, Liu QY, Jiang ZL (2018) Aptamer based determination of Pb(II) by SERS and by exploiting the reduction of HAuCl4 by H2O2 as catalyzed by graphene oxide nanoribbons. Microchim Acta 185:177–184

    Article  Google Scholar 

  • Liang AH, Li CN, Wang XL, Luo YH, Wen GQ, Jiang ZL (2017) Immunocontrolling graphene oxide catalytic nanogold reaction and its application to SERS quantitative analysis. ACS Omega 2:7349–7358

    Article  CAS  Google Scholar 

  • Liang AH, Li X, Zhang XH, Wen GQ, Jiang ZL (2018) A sensitive SERS quantitative analysis method for Ni2+ by the dimethylglyoxime reaction regulating a graphene oxide nanoribbon catalytic gold nanoreaction. Luminescence 33:1033–1039

    Article  CAS  Google Scholar 

  • Luo Y, Zhang X, Yao D, Wen G, Liu Q, Liang A, Jiang Z (2014) Resonance Rayleigh scattering detection of trace PDGF based on catalysis of aptamer-modified nanogold probe on the Fehling reaction. RSC Adv 4:28052–28055

    Article  CAS  Google Scholar 

  • Ly N, Lam A, Nguyen D, Kwark Y, Joo S (2017) Glucose-induced and fructose-induced deboronation reaction of 4-mercaptophenylboronic acid assembled on silver investigated by surface-enhanced Raman scattering. Surf Interface Anal 49:495–502

    Article  CAS  Google Scholar 

  • Ma JL, Yin BC, Wu X, Ye BC (2017) Simple and cost-effective glucose detection based on carbon nanodots supported on silver nanoparticles. Anal Chem 89:1323–1328

    Article  CAS  Google Scholar 

  • Mao GB, Cai Q, Wang FB, Luo CL, Ji XH, He ZK (2017) One-step synthesis of rox-DNA functionalized CdZnTeS quantum dots for the visual detection of hydrogen peroxide and blood glucose. Anal Chem 89:11628–11635

    Article  CAS  Google Scholar 

  • Ouyang HX, Ling SM, Liang AH, Jiang ZL (2018) A facile aptamer-regulating gold nanoplasmonic SERS detection strategy for trace lead ions. Sens Actuators B 258:739–744

    Article  CAS  Google Scholar 

  • Parham H, Pourreza N, Marahel F (2015) Resonance Rayleigh scattering method for determination of 2-mercaptobenzothiazole using gold nanoparticles probe. Spectrochim Acta Part A 151:308–314

    Article  CAS  Google Scholar 

  • Peng J, Weng J (2017) Enhanced peroxidase-like activity of MoS2/graphene oxide hybrid with light irradiation for glucose detection. Biosens Bioelectron 89:652–658

    Article  CAS  Google Scholar 

  • Vaishanav SK, Korram J, Nagwanshi R, Ghosh KK, Satnami ML (2017) Mn2+ doped-CdTe/ZnS modified fluorescence nanosensor for detection of glucose. Sens Actuators B 245:196–204

    Article  CAS  Google Scholar 

  • Wang XJ, Guo YX, Zhang ZX (2013) Field-effect transistors based on single graphene oxide nanoribbon from longitude-unzipped carbon nanotubes. J Nanopart Res 15:2147–2152

    Article  Google Scholar 

  • Wang QQ, Zhang XP, Huang L, Zhang ZQ, Dong SJ (2017a) One-pot synthesis of Fe3O4 nanoparticle loaded 3D porous graphene nanocomposites with enhanced nanozyme activity for glucose detection. ACS Appl Mater Interfaces 9:7465–7471

    Article  CAS  Google Scholar 

  • Wang W, Kong LY, Zhu JM, Tan L (2017b) One-pot preparation of conductive composite containing boronic acid derivative for non-enzymatic glucose detection. J Colloid Interface Sci 498:1–8

    Article  CAS  Google Scholar 

  • Wei S, Jun S, Seah JYH, Shi L, Tang S, Lee HK (2017) Needle-based sampling coupled with colorimetric reaction catalyzed by layered double hydroxide peroxidase mimic for rapid detection of the change of d-glucose levels with time in bananas. Anal Chim Acta 1001:32–39

    Google Scholar 

  • Wen GQ, Jing Q, Liang AH, Jiang ZL (2018) A new SERS strategy for quantitative analysis of trace microalbuminuria based on immunorecognition and graphene oxide nanoribbon catalysis. Int J Nanomed 13:6099–6107

    Article  CAS  Google Scholar 

  • Wu ZL, Li CK, Yu JG, Chen XQ (2017) MnO2/reduced graphene oxide nanoribbons: facile hydrothermal preparation and their application in amperometric detection of hydrogen peroxide. Sens Actuators B 239:544–552

    Article  CAS  Google Scholar 

  • Yao D, Wen G, Jiang Z (2013) A highly sensitive and selective resonance Rayleigh scattering method for bisphenol A detection based on the aptamer–nanogold catalysis of the HAuCl4–vitamin C particle reaction. RSC Adv 3:13353–13356

    Article  CAS  Google Scholar 

  • Ye L, Wen G, Ouyang H, Liu Q, Liang A, Jiang ZL (2016) A novel and highly sensitive nanocatalytic surface plasmon resonance-scattering analytical platform for detection of trace Pb ions. Sci Rep 6:24150–24159

    Article  CAS  Google Scholar 

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This work was supported by the National Natural Science Foundation of China (No. 21567005, 21767004).

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Correspondence to Zhi-Liang Jiang.

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Yao, DM., Liu, QY. & Jiang, ZL. Graphene oxide nanoribbon catalysis of gold nanoreaction and its application to SERS quantitative analysis of ultratrace glucose. Chem. Pap. 74, 1059–1069 (2020).

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