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Chemical Papers

, Volume 73, Issue 5, pp 1153–1162 | Cite as

Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines

  • Parvin KumarEmail author
  • Kulbir Kadyan
  • Meenakshi Duhan
  • Jayant Sindhu
  • Khalid Hussain
  • Sohan Lal
Original Paper
  • 53 Downloads

Abstract

An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.

Keywords

Silica supported CAN 1,4-DHP Ultrasonication Oxidation 

Notes

Acknowledgements

Kulbir Kadyan thanks UGC for providing junior research fellowship (JRF).

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Supplementary material

11696_2018_666_MOESM1_ESM.docx (1.3 mb)
Supplementary material 1 (DOCX 1356 kb)

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2018

Authors and Affiliations

  1. 1.Department of ChemistryKurukshetra UniversityKurukshetraIndia
  2. 2.Department of ChemistryK. M. Government CollegeNarwanaIndia
  3. 3.Chemistry DepartmentMewat Engineering CollegePalla, NuhIndia

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