Abstract
The present investigation focuses on the synthesis of silver nanoparticles (Ag-NPs)-loaded hydrogel from synthetic and lab-made carboxymethyl cellulose (CMC) using bamboo as a raw material. The Ag-NPs were made by in situ process by the reaction of CMC and epichlorohydrin in alkaline medium containing silver nitrate. CMC acts as a stabilizer and reducing agent in the formation of nanoparticles. The formation of Ag-NPs was confirmed by UV–Vis spectrophotometer, as an absorption peak around 425 nm was observed. The Ag-NPs antibacterial activity against Escherichia coli (ATCC 433), Bacillus subtilis (ATCC 1688) was calculated by agar disk diffusion technique method. The characterization of the Ag-NPs was done by FTIR, SEM, TEM, particle size analyzer and EDX. Ag-NPs obtained from lab-made CMC displayed a higher antibacterial action towards Gram-negative (Escherichia coli) bacteria as well as Gram-Positive bacteria (Bacillus subtilis) as compared to synthetic CMC obtained from market.
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References
Abdel-Halima ES, Alanazi HH, Al-Deyab SS (2015) Utilization of hydroxypropyl cellulose in synthesis of silver nanoparticles. Int J Biol Macromol 75:467–473. https://doi.org/10.1016/j.ijbiomac.2015.02.010
Anandalakshmi K, Venugobal J, Ramasamy V (2016) Characterization of silver nanoparticles by green synthesis method using Pedalium murex leaf extract and their antibacterial activity. Appl Nanosci 6:399–408. https://doi.org/10.1007/s13204-015-0449-z
Basuny M, Ali IO, Abd El-Gawad A, Bakr MF, Salama TM (2015) A fast green synthesis of Ag nanoparticles in carboxymethyl cellulose (CMC) through UV irradiation technique for antibacterial applications. J Sol Gel Sci Technol. https://doi.org/10.1007/s10971-015-3723-3
Butun S, Ince FG, Erdugan H, Sahiner N (2011) One-step fabrication of biocompatible carboxymethyl cellulose polymeric particles for drug delivery systems. Carbohydr Polym 86:636–643. https://doi.org/10.1016/j.carbpol.2011.05.001
Chang C, Duan B, Cai J, Zhang L (2010) Superabsorbent hydrogels based on cellulose for smart swelling and controllable delivery. Eur Polym J 46:92–100. https://doi.org/10.1016/j.eurpolymj.2009.04.033
Erjaee H, Rajaian H, Nazifi S (2017) Synthesis and characterization of novel silver nanoparticles using Chamaemelum nobile extract for antibacterial application. Adv Nat Sci Nanosci Nanotechnol 8:025004. https://doi.org/10.1088/2043-6254/aa690b
Goia DV (2004) Preparation and formation mechanisms of uniform metallic particles in homogeneous solutions. J Mater Chem 14:451–458. https://doi.org/10.1039/B311076A
Gulati I, Park J, Maken S, Lee M-G (2014) Production of carboxy methyl cellulose fibers from waste lignocellulosic sawdust using NaOH/NaClO2 pretreatment. Fibers Polym 15:680–686. https://doi.org/10.1007/s12221-014-0680-3
Hebeish AA, El-Rafie MH, Abdel-Mohdy FA, Abdel-Halim ES, Emam HE (2010) Carboxymethyl cellulose for green synthesis and stabilization of silver nanoparticles. Carbohydr Polym 82:933–941. https://doi.org/10.1016/j.carbpol.2010.06.020
Hebeish A, Hashem M, Abd El-Hady MM, Sharaf S (2013) Development of CMC hydrogels loaded with silver nano-particles for medical applications. Carbohydr Polym 92:407–413. https://doi.org/10.1016/j.carbpol.2012.08.094
Ibrahim SM, El Salmawi KM, Zahran AH (2007) Synthesis of crosslinked superabsorbent carboxymethyl cellulose/acrylamide hydrogels through electron-beam irradiation. J Appl Polym Sci 104:2003–2008. https://doi.org/10.1002/app.25916
Krishnaraj C, Jagan EG, Rajasekar S, Selvakumar P, Kalaichelvan PT, Mohan N (2010) Synthesis of silver nanoparticles using Acalypha indica leaf extracts and its antibacterial activity against water borne pathogens. Colloids Surf B 76:50–56. https://doi.org/10.1016/j.colsurfb.2009.10.008
Lustosa AKMF, de Jesus Oliveira AC, Quelemes PV, Placido A, da Silva FV, Oliveira IS, de Almeida MP, Amorim ADGN, Delerue-Matos C, Eaton P (2017) In situ synthesis of silver nanoparticles in a hydrogel of carboxymethyl cellulose with phthalated-cashew gum as a promising antibacterial and healing agent. Int J Mol Sci 18:1–15. https://doi.org/10.3390/ijms18112399
Paredes D, Ortiz C, Torres R (2014) Synthesis, characterization, and evaluation of antibacterial effect of Ag nanoparticles against Escherichia coli O157:H7 and methicillin resistant Staphylococcus aureus (MRSA). Int J Nanomed 9:1717–1729. https://doi.org/10.2147/IJN.S57156
Pedroza-Toscano MA, López-Cuenca S, Rabelero-Velasco M, Moreno-Medrano ED, Mendizabal-Ruiz AP, Salazar-Pena R (2017) Silver nanoparticles obtained by semicontinuous chemical reduction using carboxymethyl cellulose as a stabilizing agent and its antibacterial capacity. J Nanomater. https://doi.org/10.1155/2017/1390180
Pourjavadi A, Barzegar Sh, Mahdavinia GR (2006) MBA-crosslinked Na-Alg/CMC as a smart full-polysaccharide superabsorbent hydrogels. Carbohydr Polym 66:386–395. https://doi.org/10.1016/j.carbpol.2006.03.013
Sun XF, Feng Y, Shi X, Wang Y (2016) Preparation and property of xylan/poly(methacrylic acid) semi-interpenetrating network hydrogel. Int J Polym Sci. https://doi.org/10.1155/2016/8241078
Thomas V, Yallapu MM, Sreedhar B, Bajpai SK (2007) A versatile strategy to fabricate hydrogel–silver nanocomposites and investigation of their antimicrobial activity. J Colloid Interface Sci 315:389–395. https://doi.org/10.1016/j.jcis.2007.06.068
Tomsic B, Simonc B, Orel B, Zerjav M, Schroers H, Simonc A, Samardz Z (2009) Antimicrobial activity of AgCl embedded in a silica matrix on cotton fabric. Carbohydr Polym 75:618–626. https://doi.org/10.1016/j.carbpol.2008.09.013
Vimala K, Murali Mohan Y, Samba Sivudua K, Varaprasada K, Ravindra S, Narayana Reddya N, Padma Y, Sreedhar B, MohanaRajun K (2010) Fabrication of porous chitosan films impregnated with silver nanoparticles: a facile approach for superior antibacterial application. Colloids Surf B 76:248–258. https://doi.org/10.1016/j.colsurfb.2009.10.044
Yang S, Fu S, Liu H, Zhou Y, Li X (2010) Hydrogels beads based on carboxymethyl cellulose for removal of heavy metal ions. J Appl Polym Sci 119:1204–1210. https://doi.org/10.1002/app.32822
Acknowledgements
We greatly acknowledge the support of CIR, MNNIT Allahabad and department of physics, Allahabad University for permitting us to use analytical instruments.
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Kumar, H., Gaur, A., Kumar, S. et al. Development of silver nanoparticles-loaded CMC hydrogel using bamboo as a raw material for special medical applications. Chem. Pap. 73, 953–964 (2019). https://doi.org/10.1007/s11696-018-0650-0
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DOI: https://doi.org/10.1007/s11696-018-0650-0
Keywords
- Carboxymethyl cellulose
- Silver nanoparticles (Ag-NPs)
- Silver nitrate
- Antibacterial activity
- Hydrogel