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A simple procedure for the synthesis of novel 3-(benzofur-2-yl)pyrazole-based heterocycles

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Abstract

3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde was used, as a precursor for the synthesis of a series of novel heterocycles by facile reactions with 3-oxo-3-phenylpropanenitrile, 2-cyanoethanethioamide, and various hydrazides such as cyanoacetohydrazide, acetohydrazide, and carbohydrazide derivatives. The structures of the products were confirmed by various spectroscopic methods along with the X-ray crystal structures.

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Acknowledgements

The project was supported by King Saud University, Deanship of Scientific Research, Research Chairs.

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Correspondence to Bakr F. Abdel-Wahab or Gamal A. El-Hiti.

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Baashen, M.A., Abdel-Wahab, B.F. & El-Hiti, G.A. A simple procedure for the synthesis of novel 3-(benzofur-2-yl)pyrazole-based heterocycles. Chem. Pap. 71, 2159–2166 (2017). https://doi.org/10.1007/s11696-017-0209-5

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