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Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene

  • CHPA-D-16-00184.1
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Abstract

A fast, mild, and practical microwave-assisted protocol for synthesis of 1,4-bis(difluoromethyl)benzene from 1,4-bis(dichloromethyl)benzene and KF was developed. The new protocol increased the yield and reduced the reaction time significantly in contrast to the conventional heating procedure. Also, the synergistic effect of a composite phase transfer catalyst was studied.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Nos. 21276050 and 21406034), Fundamental Research Funds for the central Universities (No. 3207045414).

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Author notes

  1. Guo-Min Xiao

    Present address: School of Chemistry and Chemical Engineering, Southeast University, 2 Dongnan Daxue Road, Nanjing, 211189, Jiangsu, People’s Republic of China

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, People’s Republic of China

    Dong-Hui Pan, Tong-Zhen Wang & Guo-Min Xiao

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  1. Dong-Hui Pan
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  2. Tong-Zhen Wang
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Correspondence to Guo-Min Xiao.

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Pan, DH., Wang, TZ. & Xiao, GM. Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene. Chem. Pap. 71, 1249–1254 (2017). https://doi.org/10.1007/s11696-016-0118-z

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