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Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis

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Abstract

CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD). This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels. A systematic review was performed using Embase, Google Scholar, PubMed, Scopus, and Web of Science. The meta-analysis was provided by Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was detected by a random-effects meta-analysis and the leave-one-out approach. Random-effects meta-analysis of 7 studies including 191 subjects showed a significant reduction in CD40L after bariatric surgery (standardized mean difference (SMD), − 0.531; 95% CI, − 0.981, − 0.082; p = 0.021; I2, 87.00). Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

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Funding

This work was supported by the Russian Science Foundation (Grant # 24-45-20004).

Author information

Author notes

  1. Tannaz Jamialahamdi and Ali H. Eid contributed equally to this work.

Authors and Affiliations

  1. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  2. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  3. Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar

    Ali H. Eid

  4. Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA

    Ninh T. Nguyen & Kishore M. Gadde

  5. Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, 125315, Russia

    Vasily N. Sukhorukov

  6. Petrovsky National Research Centre of Surgery, Moscow, Russia

    Vasily N. Sukhorukov

  7. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

    Wael Almahmeed

  8. Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA

    Matthew Kroh

  9. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

    Amirhossein Sahebkar

  10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  11. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

Authors
  1. Tannaz Jamialahamdi
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  2. Ali H. Eid
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  3. Ninh T. Nguyen
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  4. Kishore M. Gadde
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  5. Vasily N. Sukhorukov
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  8. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar.

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Key Points

• CD40 and its ligand have been recently implicated in the pathogenesis of cardiovascular disease (CVD).

• This meta-analysis examined the effect of bariatric surgery in reducing circulating CD40L levels.

• Circulating levels of CD40L are decreased after bariatric surgery which may represent a mechanism for improvement of metabolic profile.

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Jamialahamdi, T., Eid, A.H., Nguyen, N.T. et al. Bariatric Surgery Improves Serum CD40L Levels as a Predictor of Cardiovascular Risk: Systematic Review and Meta-analysis. OBES SURG 34, 1929–1937 (2024). https://doi.org/10.1007/s11695-024-07210-8

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  • DOI: https://doi.org/10.1007/s11695-024-07210-8

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