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Bariatric Surgery in Patients with Achondroplasia, a Feasibility Study of Two Case Studies

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Abstract

Background

Achondroplasia is a common skeletal dysplasia with a high prevalence of obesity in adulthood. Bariatric surgery has been shown to be effective in treating obesity and related comorbidities, but its feasibility and effectiveness in patients with achondroplasia have not been clearly established.

Objectives

The objective of this study was to evaluate the feasibility and effectiveness of bariatric surgery in patients with achondroplasia.

Setting

This study was performed in France, and bariatric surgeons from the Société Française et Francophone de Chirurgie de l'Obésité et des Maladies Métaboliques (French Francophone Society of Surgery for Obesity or Metabolic Diseases) were asked to participate.

Methods

Two adult women with confirmed achondroplasia and a high BMI were selected for laparoscopic sleeve gastrectomy. Preoperative data were collected, including demographic information, comorbidities, and follow-up at 1, 3, and 6 months and 1 year after surgery. Complications were monitored and recorded.

Results

Both patients had good excess weight loss outcomes, with an average excess weight loss of 60.5% 1 year after surgery. One patient had a follow-up of 3 years and an excess weight loss of 44%. The surgery was well-tolerated, and no major complications were observed.

Conclusions

Bariatric surgery is feasible and effective in patients with achondroplasia, with good outcomes for excess weight loss and related comorbidities. These findings suggest that bariatric surgery should be considered a treatment option for patients with achondroplasia and obesity.

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References

  1. Krakow D, Rimoin DL. The skeletal dysplasias. Genet Med Off J Am Coll Med Genet. 2010;12(6):327–41.

    Google Scholar 

  2. Coi A, Santoro M, Garne E, et al. Epidemiology of achondroplasia: a population-based study in Europe. Am J Med Genet A. 2019;179(9):1791–8.

    Article  PubMed  Google Scholar 

  3. McDonald EJ, De Jesus O. Achondroplasia. [Updated 2023 Aug 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559263/

  4. Shirley ED, Ain MC. Achondroplasia: manifestations and treatment. J Am Acad Orthop Surg avr. 2009;17(4):231–41.

    Article  Google Scholar 

  5. Laederich MB, Horton WA. Achondroplasia: pathogenesis and implications for future treatment. Curr Opin Pediatr. 2010;22(4):516–23.

    Article  PubMed  Google Scholar 

  6. Hecht JT, Francomano CA, Horton WA, et al. Mortality in achondroplasia. Am J Hum Genet. 1987;41(3):454–64.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Saint-Laurent C, Garde-Etayo L, Gouze E. Obesity in achondroplasia patients: from evidence to medical monitoring. Orphanet J Rare Dis. 2019;14(1):253.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Saint-Laurent C, Garcia S, Sarrazy V, et al. Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia. PLoS ONE. 2018;13(4):e0195876.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Richette P, Bardin T, Stheneur C. Achondroplasia: from genotype to phenotype. Joint Bone Spine. 2008;75(2):125–30.

    Article  PubMed  Google Scholar 

  10. Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet Lond Engl. 2007;370(9582):162–72.

    Article  CAS  Google Scholar 

  11. Hecht JT, Hood OJ, Schwartz RJ, et al. Obesity in achondroplasia. Am J Med Genet. 1988;31(3):597–602.

    Article  CAS  PubMed  Google Scholar 

  12. Shirley ED, Ain MC. Achondroplasia: manifestations and treatment. J Am Acad Orthop Surg. 2009;17(4):231–41.

    Article  PubMed  Google Scholar 

  13. Hunter AG, Hecht JT, Scott CI. Standard weight for height curves in achondroplasia. Am J Med Genet. 1996;62(3):255–61.

    Article  CAS  PubMed  Google Scholar 

  14. Unger S, Bonafé L, Gouze E. Current care and investigational therapies in achondroplasia. Curr Osteoporos Rep avr. 2017;15(2):53–60.

    Article  Google Scholar 

  15. Abrão MA, da Silveira VG, de Almeida BCFLV, et al. Anesthesia for bariatric surgery in an achondroplastic dwarf with morbid obesity. Rev Bras Anestesiol févr. 2009;59(1):79–86.

    Article  Google Scholar 

  16. Carneiro JRI, da Silveira VG, Vasconcelos ACN, et al. Bariatric surgery in a morbidly obese achondroplasic patient–use of the 6-minute walk test to assess mobility and quality of life. Obes Surg févr. 2007;17(2):255–7.

    Article  Google Scholar 

  17. Obésité : prise en charge chirurgicale chez l’adulte. 2009; 2024. Available from: https://www.has-sante.fr/upload/docs/application/pdf/2011-12/recommandation_obesite_-_prise_en_charge_chirurgicale_chez_ladulte.pdf.

  18. El Moussaoui I, Van Vyve E, Johanet H, et al. Five-year outcomes of sleeve gastrectomy: a prospective multicenter study. Am Surg. 2021; 000313482199198.

  19. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chirurgie Cancérologique, Digestive Et Endocrinienne, Centre Hospitalier Universitaire de Nantes, Nantes, France

    Frédéric de la Codre, Marie de Montrichard & Claire Blanchard

  2. Service de Chirurgie Viscérale Et Digestive, Santé Atlantique, Saint-Herblain, France

    Frédéric de la Codre

  3. Service de Chirurgie Viscérale Et Digestive, Clinique Brétéché, Nantes, France

    Frédéric de la Codre

  4. L’Institut du Thorax, Inserm UMR-S1087, CNRS, UNIV Nantes, Nantes, France

    David Jacobi

  5. Département de Chirurgie Viscérale, Centre Hospitalier de Saint - Denis, Saint-Denis, France

    Jean-Marc Catheline & Claire Blanchard

  6. Département de Chirurgie Digestive Et Hépatobiliaire, Centre Hospitalier Privé Saint Grégoire, Saint Gregoire, France

    Litavan Khamphommala

Authors
  1. Frédéric de la Codre
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  2. David Jacobi
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  3. Jean-Marc Catheline
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  4. Litavan Khamphommala
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  5. Marie de Montrichard
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  6. Claire Blanchard
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Corresponding author

Correspondence to Claire Blanchard.

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Ethics Approval

This retrospective anonym cohort study does not require an ethical opinion in France.

Conflict of Interest

The authors declare no competing interests.

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de la Codre, F., Jacobi, D., Catheline, JM. et al. Bariatric Surgery in Patients with Achondroplasia, a Feasibility Study of Two Case Studies. OBES SURG 34, 1949–1953 (2024). https://doi.org/10.1007/s11695-024-07144-1

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  • DOI: https://doi.org/10.1007/s11695-024-07144-1

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