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Systematic Review and Meta-analysis of the Effects of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Dyslipidemia

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Abstract

The aim of this meta-analysis was to compare the effects of LRYGB and LSG on dyslipidemia. Studies comparing the effects of LRYGB and LSG on dyslipidemia with follow-up of 12 months or more were included. Twenty-four studies comprising seven RCTs and 17 comparative observational studies were included. Meta-analysis of RCTs (n=487) showed that improvement/resolution of dyslipidemia was better after LRYGB (68.5%, n=161/235) compared to LSG (48.4%, n=122/252). Patients undergoing LRYGB were more than twice as likely to experience improvement/resolution in dyslipidemia compared to those undergoing LSG (OR 2.28, 95% CI 1.21–4.29, p=0.010). Both LRGYB and LSG appears effective in improving dyslipidemia at >12 months after surgery; however, this improvement is more than twice higher after LRYGB compared to LSG.

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Authors and Affiliations

  1. Department of Bariatric & Upper GI Surgery, Luton & Dunstable Hospital, Bedfordshire Hospitals NHS Foundation Trust, Lewsey Road, Luton, LU4 0DZ, UK

    Md Tanveer Adil, Minali Perera, Douglas Whitelaw, Periyathambi Jambulingam, Omer Al-Taan, Aruna Munasinghe, Farhan Rashid, Amjid Riaz, Vigyan Jain & Alan Askari

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  1. Md Tanveer Adil
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  2. Minali Perera
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All authors contributed to the data collection, analysis, and write-up of the study.

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Correspondence to Md Tanveer Adil.

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Key Points

1. The meta-analysis compared the effects of LRYGB and LSG on dyslipidemia with a focus on outcomes after 12 months or more.

2. Results revealed that LRYGB had a significantly higher rate of improvement/resolution of dyslipidemia (68.5%) compared to LSG (48.4%).

3. The odds of experiencing improvement/resolution in dyslipidemia were more than twice as high for patients undergoing LRYGB (OR 2.28, 95% CI 1.21–4.29, p=0.010) compared to LSG, indicating the superiority of LRYGB in this context.

Appendix

Appendix

figure a

Funnel plot combining both randomised trials and observational studies

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Adil, M.T., Perera, M., Whitelaw, D. et al. Systematic Review and Meta-analysis of the Effects of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Dyslipidemia. OBES SURG 34, 967–975 (2024). https://doi.org/10.1007/s11695-023-07022-2

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