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Impact of Helicobacter pylori Status on Postoperative Morbidities After Laparoscopic Sleeve Gastrectomy in an Endemic Region (a Retrospective Multicentric Study)

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Abstract

Purpose

Studies are still ongoing to determine whether Helicobacter pylori (HP) may affect the results of laparoscopic sleeve gastrectomy (LSG). The main research objectives were HP prevalence in patients with severe obesity and the effects of HP status on outcomes.

Patients and Methods

This multicenter retrospective study included patients with severe obesity who had LSG. The patients were grouped into three groups based on the HP status of preoperative endoscopic biopsies and postoperative specimen results: group I (negative HP), group II (eradicated HP), and group III (positive HP). The primary outcome was the overall postoperative morbidities.

Results

One thousand six hundred fifteen patients who underwent LSG for severe obesity were included in this study. Seven hundred fifty (46.4%) patients had negative HP, and 637 (39.4%) patients had eradicated HP, whereas 228 (14.1%) patients had positive HP. The antral and gastric body wall thickness was significantly noticed with positive HP. The groups had no significant differences regarding postoperative complication frequency, severity, and hospital mortality. The rates of gastric leakage in the three groups do not differ significantly. BMI > 50, gastropexy, gastric thickness, and antral resection were found to be independent risk factors for the occurrence of postoperative complications after LSG. There was no statistical significance as regards postoperative %TWL and %EWL among the three groups.

Conclusion

The early results of LSG do not appear to be impacted by HP’s status. The early postoperative course is unaffected by HP eradication anymore. Therefore, routine preoperative HP testing may not be as necessary, and management can be finished after LSG.

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Author information

Authors and Affiliations

  1. Gastroenterology Surgical Center 1 Mansoura University, Mansoura, 35516, Egypt

    Ayman El Nakeeb, Ali Salem, Mohamed El Sorogy, Mohamad Elrefai, Aly E. Rashad & Mohamed Attia

  2. Wadi Aldawaser Armed Forces Hospital, 18511, Wadi Aldawaser, Saudi Arabia

    Ayman El Nakeeb, Aly E. Rashad, Ahmed Zaid, Hassan Maged Aldossary, Mahmoud D. Dabobash & Kalthoum Sboui

  3. Minia University Hospital, Minya, 61519, Egypt

    Alaa Mostafa Sewefy, Taha Kayed & Mohammed M. Mohammed

Authors
  1. Ayman El Nakeeb
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  2. Ali Salem
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  3. Mohamed El Sorogy
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  4. Mohamad Elrefai
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Contributions

Study conception and design: AEN, TK, AS, HMA, MA, MDD.

Acquisition of data: AER, AEN, HA, AZ, AS, MA, MDD, AZ, KS, TK, AMS, MMM, MES, ME.

Analysis and interpretation of data: AEN, HMA, AER, KS, MA, MES, ME, TK.

Critical revision of the manuscript: AEN, HMA, AS, MA, MES, ME, TK.

The manuscript has been seen and approved by all authors.

Corresponding author

Correspondence to Ayman El Nakeeb.

Ethics declarations

Consent to Participate

Informed consent was obtained from all individual participants included in the study.

Competing Interests

The authors declare no competing interests.

Ethics Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This manuscript has not been submitted for publication in any other journal and will not subsequently be submitted for potential publication in another journal until a decision has been made, nor has it been published previously in any media.

Key Points

• HP is not related to increased early postoperative morbidities following LSG.

• The antral and gastric body wall thickness was significantly noticed with positive HP.

• Eradication of HP does not have an impact on surgical outcomes of LSG.

• Routine preoperative HP testing may have restricted value in LSG.

• HP management can be finished after LSG.

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El Nakeeb, A., Salem, A., El Sorogy, M. et al. Impact of Helicobacter pylori Status on Postoperative Morbidities After Laparoscopic Sleeve Gastrectomy in an Endemic Region (a Retrospective Multicentric Study). OBES SURG 34, 183–191 (2024). https://doi.org/10.1007/s11695-023-06961-0

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  • DOI: https://doi.org/10.1007/s11695-023-06961-0

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