Skip to main content

Advertisement

SpringerLink
Log in

Association of Bariatric Surgery with Risk of Incident Obesity-Associated Malignancies: a Multi-center Population-Based Study

  • Original Contributions
  • Published:
Obesity Surgery Aims and scope Submit manuscript

Abstract

Introduction

Obesity has a known association with certain types of malignancy, and we aimed to determine whether bariatric surgery has a protective effect against de novo obesity-associated cancer development in adult patients.

Methods

We performed a multi-center retrospective cohort studying utilizing TriNetX national database. Patients were identified utilizing ICD-10-CM coding, and propensity score matching was performed. We compared patients with obesity who underwent bariatric surgery to patients with obesity who did not undergo bariatric surgery.

Results

We initially identified 60,285 patients in the bariatric surgery group and 1,570,440 patients in nonsurgical control group. After propensity score matching, we included 55,789 patients in each patient cohort. The cumulative incidence of de novo obesity-associated cancers at 10 years was 4.0% (2206 patients) in the bariatric surgery group and 8.9% (4,960 patients) in the nonsurgical control group (HR 0.482 [95% CI 0.459–0.507]). The bariatric surgery group had lower incidence proportions for de novo breast cancer (HR 0.753 [CI 0.678–0.836]), colon cancer (HR 0.638 [CI 0.541–0.752]), liver cancer (HR 0.370 [CI 0.345–0.396]), ovarian cancer (HR 0.654 [CI 0.531–0.806]), and endometrial cancer (HR 0.448 [CI 0.362–0.556]) when compared to the nonsurgical control group.

Conclusion

We noted that bariatric surgery is associated with a significantly lower cumulative incidence of de novo obesity-associated cancer compared to a nonsurgical matched control group. Incidence proportions of de novo breast, colon, liver, ovarian, and endometrial cancer were significantly lower in adult patients with obesity in the bariatric surgery group compared to the nonsurgical group.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and cancer--viewpoint of the IARC Working Group. N Engl J Med. 2016;375(8):794–8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Arterburn DE, Telem DA, Kushner RF, et al. Benefits and risks of bariatric surgery in adults: a review. JAMA. 2020;324(9):879–87.

    Article  PubMed  Google Scholar 

  3. Schauer DP, Feigelson HS, Koebnick C, et al. Bariatric surgery and the risk of cancer in a large multisite cohort. Ann Surg. 2019;269(1):95–101.

    Article  PubMed  Google Scholar 

  4. Aminian A, Wilson R, Al-Kurd A, et al. Association of bariatric surgery with cancer risk and mortality in adults with obesity. JAMA. 2022;327(24):2423–33.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Sjöström L, Gummesson A, Sjöström CD, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653–62.

    Article  PubMed  Google Scholar 

  6. Elixhauser A, Steiner C, Harris DR, et al. Comorbidity measures for use with administrative data. Med Care. 1998;36(1):8–27.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Digestive Health Institute, University Hospitals, Cleveland, OH, USA

    Vibhu Chittajallu, Emad Mansoor & Jaime Perez

  2. Cleveland Clinic Foundation, Cleveland, OH, USA

    Yazan Abu Omar, Stephen A. Firkins, Heesoo Yoo, Brian Baggott & Roberto Simons-Linares

Authors
  1. Vibhu Chittajallu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emad Mansoor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jaime Perez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yazan Abu Omar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stephen A. Firkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Heesoo Yoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Brian Baggott
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Roberto Simons-Linares
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roberto Simons-Linares.

Ethics declarations

Ethics Approval

This article does not contain any studies with human participants or animals performed by any of the authors. For this type of study, formal consent is not required.

Informed Consent

Informed consent does not apply.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Key Points

- Adult patients with obesity who underwent bariatric surgery compared with no bariatric surgery had a decreased cumulative incidence of de novo obesity-associated cancer.

- Incidence proportions of de novo breast, colon, liver, ovarian, and endometrial cancer were significantly lower in adult patients with obesity in the bariatric surgery group compared to the nonsurgical group.

Supplementary Information

ESM 1

(DOCX 19 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chittajallu, V., Mansoor, E., Perez, J. et al. Association of Bariatric Surgery with Risk of Incident Obesity-Associated Malignancies: a Multi-center Population-Based Study. OBES SURG 33, 4065–4069 (2023). https://doi.org/10.1007/s11695-023-06926-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11695-023-06926-3

Keywords

Search

Navigation