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Advanced Lipoproteins and Lipidomic Profile in Plasma Determined by Nuclear Magnetic Resonance Before and After Bariatric Surgery

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Abstract

Background

Obesity is related to cardiovascular risk factors (CVRF) such as dyslipidemia, diabetes, and hypertension, which increase mortality. Basic lipid determinations could underestimate the true atherogenic risk of patients and the impact of bariatric surgery. The objective of the study is to demonstrate the change in the advanced molecular profile of lipoproteins determined by nuclear magnetic resonance spectroscopy in plasma after bariatric surgery, thus reducing the risk of cardiovascular disease.

Material and Methods

Descriptive, observational, and prospective study in obese patients undergoing bariatric surgery. Advanced lipid profile was analyzed in plasma from the immediate preoperative period and at the 18th postoperative month by sending samples and performing plasma magnetic resonance spectroscopy in the BiosferTreslab® laboratory.

Results

Fifty-two patients were included. Average age of 46.3 years; 63.46% were women, 36.54% men. The average BMI was 43.57; the abdominal perimeter 133.50 cm; 32.6% were diabetics under medical treatment, 44.23% hypertensive, and 19.23% smokers; 86.53% of the patients presented alterations in at least one of the analytical parameters in the lipid study. Twenty-nine (55.7%) underwent banded gastric bypass (PGB), 19.23% underwent GBP, and 17.31% vertical gastrectomy. The rest were revision surgeries, two BPG-A and two biliopancreatic diversions after GV. All patients presented some improvement in advanced molecular profile of lipoproteins. Twenty percent of the patients normalized all the parameters.

Conclusions

Bariatric surgery improves advanced molecular profile of lipoproteins, decreasing CVRF. Analysis of the characteristics of lipoprotein particles by NMR spectrometry is optimal for studying lipoprotein metabolism in patients undergoing bariatric surgery.

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Funding

The study was financed with assistance from the Foundation Research Grant from the Spanish Society of Obesity Surgery (FUNSECO) awarded in 2021.

Author information

Author notes

  1. Ana Isabel Pérez Zapata, Carolina Varela Rodríguez, Cristina Martín-Arriscado Arroba, Marta Durán Ballesteros, Mercedes Bernaldo de Quirós Fernández, Nuria Amigo Grau, Eduardo Ferrero Herrero, and Elías Rodríguez Cuéllar contributed equally to this work.

Authors and Affiliations

  1. Esophagogastric and Bariatric Surgery Unit, General and Digestive System Surgery Department, Royo Villanova University Hospital, Av. de San Gregorio, S/N, 50015, Zaragoza, Spain

    Ana Isabel Pérez Zapata

  2. Healthcare Quality Unit, 12 de Octubre University Hospital, Av. de Córdoba, S/N, 28041, Madrid, Spain

    Carolina Varela Rodríguez

  3. Research and Scientific Support Unit, 12 de Octubre University Hospital, Av. de Córdoba, S/N, 28041, Madrid, Spain

    Cristina Martín-Arriscado Arroba

  4. General and Digestive System Surgery Department, Galdakao-Usansolo Hospital, Labeaga Auzoa, 48960, Galdakao, , Vizkaia, Spain

    Marta Durán Ballesteros

  5. General and Digestive System Surgery and Abdominal Organ Transplant Department, 12 de Octubre University Hospital, Av. de Córdoba, S/N, 28041, Madrid, Spain

    Mercedes Bernaldo de Quirós Fernández & Eduardo Ferrero Herrero

  6. Biosfer Teslab, Plaza Prim 10, 2N 5ª 43201, Reus, Spain

    Nuria Amigo Grau

  7. Esophagogastric and Bariatric Surgery Unit, General and Digestive System Surgery and Abdominal Organ Transplant Department, 12 de Octubre University Hospital, Av. de Córdoba, S/N, 28041, Madrid, Spain

    Elías Rodríguez Cuéllar

Authors
  1. Ana Isabel Pérez Zapata
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  2. Carolina Varela Rodríguez
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  3. Cristina Martín-Arriscado Arroba
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  4. Marta Durán Ballesteros
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  5. Mercedes Bernaldo de Quirós Fernández
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  6. Nuria Amigo Grau
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  7. Eduardo Ferrero Herrero
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  8. Elías Rodríguez Cuéllar
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Corresponding author

Correspondence to Ana Isabel Pérez Zapata.

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Human and Animal Rights/Ethics Approval

The study complied with the rules of Good Clinical Practice and was approved by the Medical Research Ethics Committee of the 12 de Octubre University Hospital.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Pérez Zapata, A.I., Varela Rodríguez, C., Martín-Arriscado Arroba, C. et al. Advanced Lipoproteins and Lipidomic Profile in Plasma Determined by Nuclear Magnetic Resonance Before and After Bariatric Surgery. OBES SURG 33, 3981–3987 (2023). https://doi.org/10.1007/s11695-023-06904-9

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  • DOI: https://doi.org/10.1007/s11695-023-06904-9

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