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The Association of Serum Irisin with Impaired Glucose Before and After Laparoscopic Sleeve Gastrectomy in Obesity

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Abstract

Background

To demonstrate the association of irisin levels with impaired glucose before and after laparoscopic sleeve gastrectomy (LSG) in patients with obesity.

Methods

Thirty-six patients with obesity undergoing LSG were included. We tested the irisin levels before and after LSG and conducted an evaluation of baseline irisin levels with elevated glucose as well as irisin changes with weight loss and its association with glucose control after LSG.

Results

Anthropometric measurements, body fat index, and metabolic parameters were significantly improved in 3 months following LSG (all p < 0.05). Baseline irisin levels were significantly higher in obesity with elevated fasting glucose than that with normal glucose (2.98 [2.37, 3.63] vs. 3.72 [3.06, 5.32], p = 0.031). After adjustment for sex, gender, and body mass index (BMI), obesity with higher irisin levels was prone to have impaired fasting glucose (OR = 2.499, 95% CI = 1.047–5.964). According to receiver operating characteristic curve analysis, the diagnostic accuracy and sensitivity of baseline irisin levels on impaired fasting glucose were 75% and 77.8%. Irisin levels decreased from 3.29 (2.67, 4.43) to 2.82 (2.41, 3.25) ng/mL (p = 0.009) after LSG. The decreases of weight, BMI, and FFA were more in irisin changes group (△irisin ≥ 0.5) than in no irisin changes group (△irisin < 0.5). And △irisin was negatively associated with postprandial glucose (PG) at 3 months after LSG (0.5 h-PG, r =  − 0.478, p = 0.029; 2 h-PG, r =  − 0.406, p = 0.017).

Conclusions

Elevated baseline irisin levels indicated the impaired glucose in obesity. The decrease of irisin with weight loss provided more evidence for the contribution of serum irisin secretion by fat mass in obesity.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, No. 301 Middle Yanchang Road, Shanghai, 200072, China

    Jiajing Yin, Shaoling Yang, Xiaojuan Zha, Zhenchun Miao, Chunjun Sheng, Peng Yang, Xingchun Wang & Shen Qu

  2. Shanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

    Jiajing Yin, Xiaojuan Zha, Zhenchun Miao, Chunjun Sheng, Peng Yang, Xingchun Wang & Shen Qu

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  1. Jiajing Yin
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  2. Shaoling Yang
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  3. Xiaojuan Zha
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  4. Zhenchun Miao
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  6. Peng Yang
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Corresponding authors

Correspondence to Xingchun Wang or Shen Qu.

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Ethics Approval and Consent to Participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The protocol of this study was approved by the Ethics Committee of Shanghai Tenth People’s Hospital. Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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Key Points

• Obesity with higher irisin levels was prone to have impaired fasting glucose.

• Irisin levels decreased after LSG.

• BMI and FFA decreased more in irisin changes group than in no irisin changes group.

• Irisin changes were negatively associated with PG at 3 months after LSG.

Jiajing Yin and Shaoling Yang contributed equally to this work and shared first authorship.

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Yin, J., Yang, S., Zha, X. et al. The Association of Serum Irisin with Impaired Glucose Before and After Laparoscopic Sleeve Gastrectomy in Obesity. OBES SURG 33, 780–788 (2023). https://doi.org/10.1007/s11695-022-06426-w

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  • DOI: https://doi.org/10.1007/s11695-022-06426-w

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