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The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

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Abstract

Currently, there is no consensus on the optimal vitamin D administration in bariatric patients. The present systematic review and meta-analysis were conducted to examine the effect of vitamin D supplements on serum level of 25(OH) vitamin D in the patients undergoing bariatric surgery (BS).

Random model effects were used to estimate standardized mean difference (SMD) with a 95% confidence interval (CI). Nine clinical trials were included in the meta-analysis. Vitamin D supplementation in patients undergoing BS modestly improves vitamin D status (SMD, 0.53; 95% CI, 0.28, 0.77) particularly, in the dosages above 2850 IU/day and in the patients with BMI greater than 50 kg/m2. Vitamin D supplementation was associated with prevention of raising of the PTH serum concentration and without impact on serum calcium levels.

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Funding

This study was funded by the Isfahan University of Medical Sciences.

Author information

Authors and Affiliations

  1. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Zeinab Mokhtari, Elham Hosseini, Zahra Faghihimani & Gholamreza Askari

  2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

    Marsa Zaroudi

  3. Department of Biology, University of British Columbia - Okanagan Campus, Kelowna, BC, V1V 1V7, Canada

    Deanna L. Gibson

  4. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Azita Hekmatdoost

  5. Biostatistics, Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

    Marjan Mansourian

  6. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Amin Salehi-Abargouei

Authors
  1. Zeinab Mokhtari
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  2. Elham Hosseini
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  5. Azita Hekmatdoost
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  7. Amin Salehi-Abargouei
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  8. Zahra Faghihimani
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  9. Gholamreza Askari
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Contributions

ZM, EH, GHA, and MM conceptualized and designed the systematic review and meta-analysis study; MZ and ZF screened the publications; MZ and EH selected; ZM and EH extracted the data and conducted the risk of bias assessment; AS confirmed the accuracy of the extraction and analyzed the data; ZM performed the GRADE assessment; ZM, EH, DG, AH, MM, and GHA interpreted the data and prepared the manuscript.

Corresponding author

Correspondence to Gholamreza Askari.

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Key Points

• Consumption of above 2850 IU/day of vitamin D might be needed in bariatric surgery.

•Serum parathyroid hormone levels were improved by vitamin D supplementation.

• Serum calcium levels were not altered by vitamin D supplementation.

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Mokhtari, Z., Hosseini, E., Zaroudi, M. et al. The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials. OBES SURG 32, 3088–3103 (2022). https://doi.org/10.1007/s11695-022-06121-w

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