Skip to main content
SpringerLink
Log in

Sleeve Gastrectomy Attenuates the Severity of Cerulein-Induced Acute Pancreatitis in Obese Rats

  • Original Contributions
  • Published:
Obesity Surgery Aims and scope Submit manuscript

Abstract

Purpose

Obesity is one of the most important risk factors for acute pancreatitis. Based on the effect of sleeve gastrectomy (SG) on improving body weight and blood lipids, we investigated whether SG is beneficial in improving pancreatitis in obese rats.

Materials and Methods

Two studies were used to evaluate the effect of SG on the first onset of pancreatitis and acute episodes of recurrent pancreatitis in obese rats. A high-fat diet (HFD) for 8 weeks resulted in obesity in rats. Study 1: Obese rats were treated with SG and sham surgery. Pancreatitis was induced by intraperitoneal injection of cerulein at 6 weeks after surgery. The severity of pancreatitis was assessed by histological examination, cytokines, and infiltration of inflammatory cells. Study 2 performed the same procedure as in study 1, except that rats were intraperitoneally injected with a small dose of cerulein three times a week for 6 weeks before surgery to induce recurrent pancreatitis.

Results

The body weight, food intake, and blood lipids of SG rats in study 1 and study 2 were significantly lower than those of sham rats during the 6 weeks after surgery. Compared with sham rats, SG rats in both studies had fewer inflammatory cytokines, inflammatory cell infiltration, and pathological injury in the pancreas after cerulein-induced acute pancreatitis.

Conclusion

SG reduces the severity of the first onset of pancreatitis and the seriousness of acute episodes of recurrent pancreatitis. The improvement of lipid metabolism and body weight by SG may play an important role in this effect.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Khatua B, El-Kurdi B, Singh VP. Obesity and pancreatitis. Curr Opin Gastroenterol. 2017;33(5):374–82.

    Article  CAS  Google Scholar 

  2. Hong YP, Yu J. High-fat diet aggravates acute pancreatitis via TLR4-mediated necroptosis and inflammation in rats. Oxidative Med Cell Longev. 2020;2020:8172714. Epub 2020 Jan 8

    Article  Google Scholar 

  3. Yashima Y, Isayama H, Tsujino T, et al. A large volume of visceral adipose tissue leads to severe acute pancreatitis. J Gastroenterol. 2011;46(10):1213–8.

    Article  Google Scholar 

  4. Hansen SEJ, Madsen CM, Varbo A, et al. Body mass index, triglycerides, and risk of acute pancreatitis: a population-based study of 118 000 Individuals. J Clin Endocrinol Metab. 2020;105(1):dgz059.

    Article  Google Scholar 

  5. Radmard AR, Merat S, Kooraki S, et al. Gallstone disease and obesity: a population-based study on abdominal fat distribution and gender differences. Ann Hepatol. 2015;14(5):702–9.

    Article  CAS  Google Scholar 

  6. Piťha J, Kovář J, Blahová T. Fasting and nonfasting triglycerides in cardiovascular and other diseases. Physiol Res. 2015;64(Suppl 3):S323–30.

    Article  Google Scholar 

  7. Navina S, Acharya C, DeLany JP, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med. 2011;3(107):107ra10.

    Article  Google Scholar 

  8. Spiegel HU, Skawran S. From longitudinal gastric resection to sleeve gastrectomy--revival of a previously established surgical procedure. J Gastrointest Surg. 2011;15(1):219–28.

    Article  Google Scholar 

  9. English WJ, DeMaria EJ, Brethauer SA, et al. American Society for Metabolic and Bariatric Surgery estimation of metabolic and bariatric procedures performed in the United States in 2016. Surg Obes Relat Dis. 2018;14(3):259–63.

    Article  Google Scholar 

  10. Kawano Y, Ohta M, Hirashita T, et al. Effects of sleeve gastrectomy on lipid metabolism in an obese diabetic rat model. Obes Surg. 2013;23(12):1947–56.

    Article  Google Scholar 

  11. Watanabe K, Ohta M, Takayama H, et al. Effects of sleeve gastrectomy on nonalcoholic fatty liver disease in an obese rat model. Obes Surg. 2018;28(6):1532–9.

    Article  Google Scholar 

  12. Song Y, Deng H, Zhou J, et al. The effects of laparoscopic sleeve gastrectomy on obesity-related hypertriglyceridemia-induced acute pancreatitis. Obes Surg. 2018;28(12):3872–9.

    Article  Google Scholar 

  13. Rong Y, Ren J, Song W, Xiang R, Ge Y, Lu W, et al. Resveratrol suppresses severe acute pancreatitis-induced microcirculation disturbance through targeting SIRT1-FOXO1 Axis. Oxidative Med Cell Longev. 2021;2021:8891544.

  14. Yamaguchi H, Weidenbach H, Lührs H, et al. Combined treatment with C1 esterase inhibitor and antithrombin III improves survival in severe acute experimental pancreatitis. Gut. 1997;40(4):531–5.

    Article  CAS  Google Scholar 

  15. Pan Y, Li Y, Gao L, et al. Development of a novel model of hypertriglyceridemic acute pancreatitis in mice. Sci Rep. 2017;7:40799.

    Article  CAS  Google Scholar 

  16. Pezzilli R, Miniero R, Cappelletti O, et al. Serum interleukin 6 in the prognosis of acute biliary pancreatitis. Ital J Gastroenterol Hepatol. 1998;30(3):291–4.

    CAS  PubMed  Google Scholar 

  17. Bhatia M, Neoptolemos JP, Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs. 2001;2(4):496–501.

    CAS  PubMed  Google Scholar 

  18. Denham W, Yang J, Fink G, et al. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. Gastroenterology. 1997;113(5):1741–6.

    Article  CAS  Google Scholar 

  19. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5(2-3):132–44.

    Article  Google Scholar 

  20. Manohar M, Verma AK, Venkateshaiah SU, et al. Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther. 2017;8(1):10–25.

    Article  Google Scholar 

  21. Awla D, Abdulla A, Zhang S, et al. Lymphocyte function antigen-1 regulates neutrophil recruitment and tissue damage in acute pancreatitis. Br J Pharmacol. 2011;163(2):413–23.

    Article  CAS  Google Scholar 

  22. Abdulla A, Awla D, Thorlacius H, et al. Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis. J Leukoc Biol. 2011;90(5):975–82.

    Article  CAS  Google Scholar 

  23. Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–47. Epub 2019/09/19

    Article  CAS  Google Scholar 

  24. Chang YT, Chang MC, Tung CC, et al. Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis. World J Gastroenterol. 2015;21(32):9534–43.

    Article  CAS  Google Scholar 

  25. Jeong YK, Kim H. A mini-review on the effect of docosahexaenoic acid (DHA) on cerulein-induced and hypertriglyceridemic acute pancreatitis. Int J Mol Sci. 2017;18(11):2239.

    Article  Google Scholar 

  26. Hussan H, Ugbarugba E, Porter K, et al. The type of bariatric surgery impacts the risk of acute pancreatitis: a nationwide study. Clin Transl Gastroenterol. 2018;9(9):179.

    Article  Google Scholar 

  27. Hsu S-Y, Ser K-H, Chong K, et al. Mini-gastric bypass surgery for hypertriglyceridemia-induced pancreatitis. Formos J Surg. 2012;45(6):187–90.

    Article  Google Scholar 

  28. Ren Y, He M, Xian Y, et al. RYGB in treating patients with obesity, hypertriglyceridemia-induced acute pancreatitis, and diabetes: kill three birds with one stone? Obes Surg. 2020;30(5):2033–5.

    Article  Google Scholar 

  29. Kröner PT, Simons-Linares CR. Acute pancreatitis in patients with a history of bariatric surgery: is it less severe? Obes Surg. 2020;30(6):2325–30.

    Article  Google Scholar 

Download references

Acknowledgements

We thank John T. Cathey for English language assistance (Peerwith, John Cathey, https://goo.gl/MSJTA7).

Funding

This study was supported by the Foundation of Sichuan Health Committee (18PJ496).

Author information

Author notes

  1. Yin Xian, Yi Wu and Ming He contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, and Institute of Hepato-Biliary-Pancreas and Intestinal Disease, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China

    Yin Xian, Yi Wu, Ming He, Junming Cheng, Xiaodong Lv & Yixing Ren

  2. Nanchong Psychosomatic Hospital, Nanchong, 637000, People’s Republic of China

    Yin Xian

Authors
  1. Yin Xian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yi Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ming He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Junming Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaodong Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yixing Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yixing Ren.

Ethics declarations

Ethics Approval

All applicable institutional and/or national guidelines for the care and use of animals were followed.

Informed Consent

Informed Consent does not apply.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Key Points

1. SG significantly improved body weight and lipid metabolism in obese rats.

2. SG reduces the severity of the first onset of pancreatitis in obese rats.

3. SG reduces the severity of acute episode of recurrent pancreatitis in obese rats.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xian, Y., Wu, Y., He, M. et al. Sleeve Gastrectomy Attenuates the Severity of Cerulein-Induced Acute Pancreatitis in Obese Rats. OBES SURG 31, 4107–4117 (2021). https://doi.org/10.1007/s11695-021-05521-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11695-021-05521-8

Keywords

Search

Navigation