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Skin Autofluorescence and Carotid Intima-Media Thickness Evaluation Following Bariatric Surgery in Patients with Severe Obesity

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Abstract

Purpose

Advanced glycation end product (AGE) is a marker of metabolic memory. Accumulated AGEs in skin collagen measured with skin autofluorescence (SAF) was found to be associated with subclinical atherosclerosis. We aimed to evaluate SAF and carotid intima-media thickness (CIMT) and its association with clinical and biochemical parameters in severely obese patients before and after bariatric surgery.

Materials and Methods

In this observational study, 432 morbid obese patients evaluated before and after 6 and 12 months of bariatric surgery for metabolic and anthropometric parameters, CIMT and SAF. SAF was assessed in the forearm with an AGE Reader.

Results

SAF measurements were higher in diabetic (2.04 ± 0.52 AU) obese patients compared to non-diabetic (1.78 ± 0.40 AU) obese patients (p < 0.0001). Although bariatric surgery-induced weight loss resulted in a decrease in CIMT in the 6th and 12th months compared to baseline, weight loss and metabolic improvements were not associated with a parallel decrease in SAF measurements. SAF measurements were positively correlated with body mass index (r 0.527, p < 0.0001), HbA1c (r 0.362, p < 0.0001), and CIMT (r 0.319, p < 0.0001). Multivariate analysis showed the presence of diabetes (but not BMI, age, and sex) was independently associated with SAF (R2 = 7.62%), and the presence of diabetes, low-density cholesterol, and systolic blood pressure were independently associated with CIMT measurements (R2 = 21.7%).

Conclusion

Bariatric surgery-induced weight loss and metabolic improvement were found to be associated with improvement in CIMT, while skin AGE accumulation was not regressed in the first year of surgery.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey

    Dilek Gogas Yavuz & Tugce Apaydin

  2. Department of Endocrinology and Metabolism, Ersin Arslan Training and Research Hospital, Gaziantep, Turkey

    Eren Imre

  3. Department of Endocrinology and Metabolism, Yeni Yuzyil University, Gaziosmanpasa Hospital, Istanbul, Turkey

    Meliha Melin Uygur

  4. Department of Endocrinology and Metabolism, Koc University Hospital, Istanbul, Turkey

    Dilek Yazici

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  1. Dilek Gogas Yavuz
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  2. Tugce Apaydin
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Contributions

All authors made substantial contributions to conception and design, and/or acquisition of data, and/or analysis and interpretation of data, participated in drafting the article or revising it critically for important intellectual content, and gave final approval of the version to be submitted.

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Correspondence to Dilek Gogas Yavuz.

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All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Gogas Yavuz, D., Apaydin, T., Imre, E. et al. Skin Autofluorescence and Carotid Intima-Media Thickness Evaluation Following Bariatric Surgery in Patients with Severe Obesity. OBES SURG 31, 1055–1061 (2021). https://doi.org/10.1007/s11695-020-05077-z

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