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Preoperative Level of Leptin Can Be a Predictor of Glycemic Control for Patients with Diabetes Undergoing Bariatric Surgery

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Abstract

Introduction

Bariatric surgery is a first-line treatment for patients with obesity and diabetes. It is uncertain whether leptin has an influence on glycemia in the postoperative period.

Methods

A cohort study of thirty-eight individuals with obesity and diabetes who underwent laparoscopic Roux-en-Y gastric bypass was undertaken. The levels of leptin, glucose, and glycosylated hemoglobin were verified in the preoperative period and in the first and third postoperative months.

Results

The majority of patients were women (81.6%), and the mean age was 47.3 years (SD 8.8). The mean BMI was reduced by 17.75% (from 47.3 to 38.9 kg/m2) and the mean glycemia by 26.76%. Preoperative leptin had a moderate positive correlation with glucose level at the third month (Pearson r = 0.46, P = 0.02), but not with HbA1c. Patients with leptin above 27.34 ng/mL had a higher glucose level at the end of observation (101.9 versus 88.9, t test, P = 0.042).

Conclusion

The search for factors that influence diabetes control after bariatric surgery is of major importance in clinical practice. Our study reported a level of leptin that can predict the prognosis of glycemic control after the intervention. This finding still needs to be validated and confirmed in other populations.

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Authors and Affiliations

  1. Post-Graduate Program on Surgery, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Luisa Ortiz Cabrera, Eduardo Neubarth Trindade & Manoel Roberto Maciel Trindade

  2. Department of Surgery, Moinhos de Vento Hospital, Porto Alegre, RS, Brazil

    Eduardo Neubarth Trindade & Manoel Roberto Maciel Trindade

  3. Department of Gastroenterology, Moinhos de Vento Hospital, Porto Alegre, RS, Brazil

    Carine Leite

  4. Porto Alegre, Brazil

    Carine Leite

  5. School of Medicine, UFRGS, Porto Alegre, RS, Brazil

    Everton Hiraiwa Abegg & Manoel Roberto Maciel Trindade

Authors
  1. Luisa Ortiz Cabrera
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  2. Eduardo Neubarth Trindade
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  4. Everton Hiraiwa Abegg
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  5. Manoel Roberto Maciel Trindade
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The authors declare that they have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Human and Animal Rights/Ethical Approval

The study was approved by the HCPA Ethical Committee number 1,959,671. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Cabrera, L.O., Trindade, E.N., Leite, C. et al. Preoperative Level of Leptin Can Be a Predictor of Glycemic Control for Patients with Diabetes Undergoing Bariatric Surgery. OBES SURG 30, 4829–4833 (2020). https://doi.org/10.1007/s11695-020-05011-3

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  • DOI: https://doi.org/10.1007/s11695-020-05011-3

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