Abstract
Purpose
Majority of men with type 2 diabetes mellitus (T2DM) have been reported to experience erectile dysfunction (ED) in a lifetime. The aim of our study was to prospectively evaluate the postoperative condition of ED and premature ejaculation (PE) in men who underwent metabolic surgery for the treatment of T2DM.
Materials and Methods
A total of 36 sexually active male individuals with T2DM who were applied for metabolic surgery were given two different questionnaire forms prior to and 6 months after the surgery. Patients filled the International Index of Erectile Function (IIEF) and the Premature Ejaculation Profile (PEP) questionnaires before and 6 months after the surgery. The BMI, fasting blood glucose (FBG), and glycated hemoglobin (HbA1c) concentrations were also measured prior to the surgery and on follow-up points of postoperative first, third, and sixth months.
Results
Erectile function (EF) and overall satisfaction domains of the IIEF questionnaire increased significantly after the surgery in the patient groups irrespective of the previous ED severity (p < 0.001). There were significant improvements of the PEP interpersonal difficulty related to ejaculation score and HbA1c levels in the severe/moderate EF group and IIEF EF, PEP interpersonal difficulty related to ejaculation domains, and HbA1c levels of mild to moderate/mild/no ED group after the metabolic surgery.
Conclusion
Metabolic surgery could improve erectile and ejaculatory function scores of obese patients with T2DM.
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References
Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381(9861):153–65. https://doi.org/10.1016/S0140-6736(12)60520-0.
Lewis RW, Fugl-Meyer KS, Corona G, et al. Definitions/epidemiology/risk factors for sexual dysfunction. J Sex Med. 2010;7(4 Pt 2):1598–607. https://doi.org/10.1111/j.1743-6109.2010.01778.x.
Keating NL, O’Malley AJ, Freedland SJ, et al. Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. J Natl Cancer Inst. 2010;102:39–46.
Traish AM, Feeley RJ, Guay A. Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. FEBS J. 2009;276:5755–67.
Wang C, Jackson G, Jones TH, et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care. 2011;34(7):1669–75. https://doi.org/10.2337/dc10-2339.
Rubino F, Nathan DM, Eckel RH, et al. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Diabetes Care. 2016;39(6):861–77. https://doi.org/10.2337/dc16-0236.
Santoro S, Castro LC, Velhote MC, et al. Sleeve gastrectomy with transit bipartition: a potent intervention for metabolic syndrome and obesity. Ann Surg. 2012;256(1):104–10. https://doi.org/10.1097/SLA.0b013e31825370c0.
Xu J, Wu Q, Zhang Y, et al. Effect of bariatric surgery on male sexual function: a meta-analysis and systematic review. Sex Med. 2019;7(3):270–81. https://doi.org/10.1016/j.esxm.2019.06.003.
Traish AM, Goldstein I, Kim NN. Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiencyand erectile dysfunction. Eur Urol. 2007;52:54–70.
Rosen R, Riley A, Wagner G, et al. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822–30.
Shabsigh R, Rowland D. The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision as an appropriate diagnostic for premature ejaculation. J Sex Med. 2007;4:1468–78.
Gorgel SN, Gorgel A, Sefik E. Sexual function in male patients with metabolic syndrome and effective parameters on erectile dysfunction. Int Braz J Urol. 2014;40(1):56–61. https://doi.org/10.1590/S1677-5538.IBJU.2014.01.08.
Malavige LS, Levy JC. Erectile dysfunction in diabetes mellitus. J Sex Med. 2009;6(5):1232–47. https://doi.org/10.1111/j.1743-6109.2008.01168.x.
Corona G, Monami M, Rastrelli G, et al. Type 2 diabetes mellitus and testosterone: a meta-analysis study. Int J Androl. 2011;34(6 Pt 1):528–40. https://doi.org/10.1111/j.1365-2605.2010.01117.x.
Colangelo LA, Ouyang P, Liu K, et al. Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis. Diabetes Care. 2009;32:1049–51.
Andersson B, Marin P, Lissner L, et al. Testosterone concentrations in women and men with NIDDM. Diabetes Care. 1994;17:405–11.
Jones TH, Saad F. The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process. Atherosclerosis. 2009;207:318–27.
Cohen PG. The hypogonadal-obesity cycle: role of aromatase in modulating the testosteroneestradiol shunt—a major factor in the genesis of morbid obesity. Med Hypotheses. 1999;52:49–51.
Aleid M, Muneer A, Renshaw S, et al. Early effect of bariatric surgery on urogenital function in morbidly obese men. J Sex Med. 2017;14(2):205–14. https://doi.org/10.1016/j.jsxm.2016.12.004.
Chitaley K. Type 1 and type 2 diabetic-erectile dysfunction: same diagnosis (ICD-9), different disease? J Sex Med. 2009;6(Suppl 3):262–8. https://doi.org/10.1111/j.1743-6109.2008.01183.x.
Gratzke C, Angulo J, Chitaley K, et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med. 2010;7(1 Pt 2):445–75. https://doi.org/10.1111/j.1743-6109.2009.01624.x.
Corona G, Mondaini N, Ungar A, et al. Phosphodiesterase type 5 (PDE5) inhibitors in erectile dysfunction: the proper drug for the proper patient. J Sex Med. 2011;8(12):3418–32. https://doi.org/10.1111/j.1743-6109.2011.02473.x.
Hirshkowitz M, Karacan I, Arcasoy MO, et al. Prevalence of sleep apnea in men with erectile dysfunction. Urology. 1990;36:232–4.
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Karaca, F.C., Taş, T. Early Effect of Metabolic Surgery on Erectile Function and Ejaculation: a Pilot Study of Obese Men with Type 2 Diabetes Mellitus. OBES SURG 30, 4768–4773 (2020). https://doi.org/10.1007/s11695-020-04879-5
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DOI: https://doi.org/10.1007/s11695-020-04879-5