Skip to main content

Advertisement

SpringerLink
Log in

Postnatal Health in Children Born to Women After Bariatric Surgery

  • Original Contributions
  • Published:
Obesity Surgery Aims and scope Submit manuscript

Abstract

Introduction

The aim of this study is to evaluate short- and long-term consequences in children born to women after different bariatric surgery (BS) procedures.

Methods

A questionnaire survey was given to the mothers referred from 1994 to 2019 to our center for pregnancy and delivery management after BS procedures: (a) malabsorptive surgery, (b) restrictive procedures, and (c) combined restrictive-malabsorptive procedures.

Results

Data from 74 children born after BS, aged 0 month to 12 years, were analyzed. The prevalence of children with underweight was 5.4%, normal weight 59.5%, overweight 16.2%, and obesity 18.9%. The prevalence of obesity was higher in children pre-school aged than that in school-aged ones. Neurodevelopmental disorders were more frequent if maternal BMI before bariatric surgery was ≥ 41 kg/m2 (p = 0.008), as well as if the pregnancy occurred less than 18 months after BS (p = 0.028). In school-aged children conceived within 18 months after BS, the highest risk of neurodevelopmental disorders (p = 0.028) and overweight (p = 0.018) was observed. The prevalence of neurodevelopmental disorders was much higher for small for gestational age babies (p = 0.048). Children born after biliopancreatic diversion (BPD) showed less maternal breastfeeding, shorter breastfeeding duration, more overweight, and more occurrence of atopic dermatitis in comparison with children born after other bariatric procedures.

Conclusions

Postnatal health in children born to women after BS was impaired by long-term consequences and by other diseases later in life. Children born after BPD were particularly at higher risk for short and long term consequences when compared to children born after other BS procedures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Starling AP, Brinton JT, Glueck DH, et al. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr United States. 2015;101:302–9.

    Article  CAS  Google Scholar 

  2. Tan HC, Roberts J, Catov J, et al. Mother’s pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr Diabetes Denmark. 2015;16:419–26.

    Article  CAS  Google Scholar 

  3. Macrì F, Pitocco D, di Pasquo E, et al. Gestational weight gain as an independent risk factor for adverse pregnancy outcomes in women with gestational diabetes. Eur Rev Med Pharmacol Sci. 2018 Jul;22(14):4403–10.

    PubMed  Google Scholar 

  4. Padwal R, Klarenbach S, Wiebe N, et al. Bariatric surgery: a systematic review of the clinical and economic evidence. J Gen Intern Med United States. 2011;26:1183–94.

    Article  Google Scholar 

  5. Picot J, Jones J, Colquitt JL, et al. Weight loss surgery for mild to moderate obesity: a systematic review and economic evaluation. Obes Surg United States. 2012;22:1496–506.

    Article  Google Scholar 

  6. Kizy S, Jahansouz C, Downey MC, et al. National trends in bariatric surgery 2012–2015: demographics, procedure selection, readmissions, and cost. Obes Surg. 2017 Nov;27(11):2933–9.

    Article  PubMed  Google Scholar 

  7. Willmer M, Berglind D, SØrensen TI, et al. Surgically induced interpregnancy weight loss and prevalence of overweight and obesity in offspring. PLoS One. 2013;8:e82247.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Institute of Medicine. Weight gain during pregnancy: reexamining the guidelines. Washington, DC: National Academies Press; 2009.

    Google Scholar 

  9. Bertino E, Spada E, Occhi L, et al. Neonatal anthropometric charts: the Italian neonatal study compared with other European studies. J Pediatr Gastroenterol Nutr. 2010;51(3):353–61.

    PubMed  Google Scholar 

  10. De Carolis S, Botta A, Del Sordo G, et al. Influence of biliopancreatic diversion on pregnancy outcomes in comparison to other bariatric surgery procedures. Obes Surg. 2018;28(10):3284–92.

    Article  PubMed  Google Scholar 

  11. Available on: https://www.epicentro.iss.it/okkioallasalute/pdf/ONLINE_OKKIO_ALLA_SALUTE.pdf.

  12. Smith J, Cianflone K, Biron S, et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab. 2009;94(11):4275–83.

    Article  CAS  PubMed  Google Scholar 

  13. Kral JG, Biron S, Simard S, et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. J Pediatrics. 2006;118(6):e1644–9.

    Article  Google Scholar 

  14. Barisione M, Carlini F, Gradaschi R, et al. Body weight at developmental age in siblings born to mothers before and after surgically induced weight loss. Surg Obes Relat Dis. 2012;8(4):387–91.

    Article  PubMed  Google Scholar 

  15. Guénard F, Deshaies Y, Cianflone K, et al. Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci U S A. 2013;110(28):11439–44.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Fernandez-Twinn DS, Ozanne SE. Mechanism by which poor early growth programs type2 diabetes, obesity and the metabolic syndrome. Physiol Behav. 2006;88(3):234–43.

    Article  CAS  PubMed  Google Scholar 

  17. Hue O, Marcotte J, Berrigan F, et al. Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery. Obes Surg. 2006;16(9):1145–54.

    Article  PubMed  Google Scholar 

  18. Godfrey KM, Reynolds RM, Prescott SL, et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol. 2017;5(1):53–64.

    Article  PubMed  Google Scholar 

  19. Korhonen P, Haataja P, Ojala R, et al. Asthma and atopic dermatitis after early-, late-, and post-term birth. Pediatr Pulmonol. 2018 Mar;53(3):269–77.

    Article  PubMed  Google Scholar 

  20. Kaska L, Kobiela J, Abacjew-Chmylko A, et al. Nutrition and pregnancy after bariatric surgery. ISRN Obes. 2013;2013:492060.

    PubMed  PubMed Central  Google Scholar 

  21. Hazart J, Le Guennec D, Accoceberry M, et al. Maternal nutritional deficiencies and small for gestational age neonates at birth of women who have undergone bariatric surgery. J Pregnancy. 2017;2017:4168541.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Hammeken LH, Betsagoo R, Jensen AN, et al. Nutrient deficiency and obstetrical outcomes in pregnant women following Roux-en-Y gastric bypass: a retrospective Danish cohort study with a matched comparison group. Eur J Obstet Gynecol Reprod Biol. 2017;216:56–60.

    Article  PubMed  Google Scholar 

  23. Gdalevich M, Mimouni D, David M, et al. Breast-feeding and the onset of atopic dermatitis in childhood: a systematic review and meta-analysis of prospective studies. J Am Acad Dermatol. 2001;45(4):520–7. Review

    Article  CAS  PubMed  Google Scholar 

  24. Gadgil MD, Chang HY, Richards TM, et al. Laboratory testing for and diagnosis of nutritional deficiencies in pregnancy before and after bariatric surgery. J Women’s Health (Larchmt). 2014;23(2):129–37.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy

    Gelsomina Del Sordo, Antonio Lanzone & Sara De Carolis

  2. UOC di Patologia Ostetrica, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    Angela Botta, Silvia Salvi, Antonio Lanzone & Sara De Carolis

  3. Department of Gynecological and Obstetric Sciences and Urological Sciences, Umberto I Hospital, Sapienza Università di Roma, Rome, Italy

    Sara Tabacco

  4. Department of Internal Medicine, Catholic University, Largo A. Gemelli 8, 00168, Rome, Italy

    Amerigo Iaconelli

  5. Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    Maria Pia De Carolis

  6. Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy, Università Cattolica del Sacro Cuore, Rome, Italy

    Marco Raffaelli

Authors
  1. Gelsomina Del Sordo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angela Botta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Silvia Salvi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sara Tabacco
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Amerigo Iaconelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Antonio Lanzone
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maria Pia De Carolis
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Marco Raffaelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sara De Carolis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Angela Botta.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

For this type of study, formal consent is not required.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Del Sordo, G., Botta, A., Salvi, S. et al. Postnatal Health in Children Born to Women After Bariatric Surgery. OBES SURG 30, 3898–3904 (2020). https://doi.org/10.1007/s11695-020-04738-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11695-020-04738-3

Keywords

Search

Navigation