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Bariatric Surgery for Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy: a Matched Case–Control Study

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Abstract

Craniopharyngioma and its treatment lead to weight gain and pituitary hormone deficiencies. This study aimed to investigate the effectiveness of bariatric surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. Five patients with hypothalamic obesity after craniopharyngioma treatment were included. Patients were treated with sleeve gastrectomy or Roux-en-Y gastric bypass and individually matched to 2 control patients treated for common obesity. At 2 years of follow-up, total and excess weight loss in cases were 14.7% (p = 0.002) and 38.0% (p = 0.001), respectively; differences between both groups were 13.6% (p = 0.02) and 31.6% (p = 0.03). Minor postoperative alterations in hormone substitution in all 5 cases were observed. Thus, bariatric surgery induced significant weight loss in patients with craniopharyngioma-related hypothalamic obesity, even though a superior weight loss in controls was observed.

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Acknowledgements

The authors would like to thank the Biostatistics Unit of the Faculty of Medicine and Health Sciences at Ghent University.

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Correspondence to Ieme Garrez.

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Conflict of Interest

Garrez I. and Lapauw B. declare that they have no conflict of interest; Van Nieuwenhove Y. reports consultancy fees from Olympus and grants from Kom op tegen kanker outside the submitted work.

Ethical Approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Garrez, I., Lapauw, B. & Van Nieuwenhove, Y. Bariatric Surgery for Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy: a Matched Case–Control Study. OBES SURG (2020). https://doi.org/10.1007/s11695-020-04391-w

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Keywords

  • Craniopharyngioma
  • Hypothalamic obesity
  • Bariatric surgery
  • Sleeve gastrectomy
  • Roux-en-Y gastric bypass
  • Hormone substitution